2018年2月8日 · MDSC depletion was associated with activation of cytotoxic T lymphocyte (CTL) responses in mice and patients. The LXR transcriptional target ApoE mediated these effects in mice, where LXR/ApoE activation therapy elicited robust anti-tumor responses and also enhanced T cell activation during various immune-based therapies.

Therapeutic agonism of the LXR/ApoE axis promotes anti-tumor immunity by targeting immunosuppressive innate immune cells. Therapeutic harnessing of adaptive immunity via checkpoint inhibition has transformed the treatment of many cancers. Despite unprecedented long-term responses, most patients do not respond to these therapies.

2023年12月1日 · 载脂蛋白E（ApoE）是大脑中最丰富的载脂蛋白，负责调节脂质和胆固醇的转运和代谢，在神经系统的正常功能和神经退行性疾病中起着关键作用。 ApoE ...

2001年1月9日 · We demonstrate here that the nuclear receptors LXRα and LXRβ and their oxysterol ligands are key regulators of apoE expression in both macrophages and adipose tissue. We show that LXR/RXR heterodimers regulate apoE transcription directly, through interaction with a conserved LXR response element present in both ME.1 and ME.2.

LXR activation enhanced the expression of hepatic apoE, together with the alteration of lipoprotein particles produced from the differentiated hepatocyte-derived cells. HepG2 spheroids might serve as a good model of well-differentiated human hepatocytes for future investigations of hepatic lipid metabolism.

2011年8月5日 · LXR activation enhanced the expression of hepatic apoE, together with the alteration of lipoprotein particles produced from the differentiated hepatocyte-derived cells. HepG2 spheroids might serve as a good model of well-differentiated human hepatocytes for future investigations of hepatic lipid met …

2018年1月11日 · LXR转录靶标ApoE在小鼠中介导了这些作用，在各种基于免疫的疗法中，LXR / ApoE激活疗法可引发强大的抗肿瘤反应，并增强T细胞活化。 我们将LXR / ApoE轴暗示于先天免疫抑制的调节中，并将其作为增强患者癌症免疫疗法功效的目标。

apoE is the primary lipid carrier within the CNS and the strongest genetic risk factor for late onset Alzheimer's disease (AD). apoE is primarily lipidated via ABCA1, and both are under transcriptional regulation by the nuclear liver X receptor (LXR). Considerable evidence from genetic (using ABCA1 …

2014年2月27日 · We uncover an important role for stromal ApoE in mediating the effects of LXR agonists on melanoma progression. Interestingly, whereas tumor growth inhibition was primarily driven by ApoE induction in stromal cells, metastasis suppression by GW3965 was elicited through the activation of both stromal and melanoma-derived ApoE (Figures 5E and

2018年2月8日 · We implicate the LXR/ApoE axis in the regulation of innate immune suppression and as a target for enhancing the efficacy of cancer immunotherapy in patients. Discoveries defining molecular checkpoints that constrain T cell activation represent a landmark in cancer treatment (Krummel and Allison, 1995; Okazaki and Honjo, 2007; Peggs et al., 2008).