LXRS and FXR: the yin and yang of cholesterol and fat metabolism
Liver X receptors (LXRs) and farnesoid X receptor (FXR) are nuclear receptors that function as intracellular sensors for sterols and bile acids, respectively. In response to their ligands, these …
Cell Metabolism | FXR激活可通过胆汁酸依赖方式降低脂质吸收从 …
目前，NALFD/NASH患者的治疗方案非常有限，不过 核受体 法尼醇X受体 (FXR) 激动剂已显示出较好的应用前景。 已有研究表明，FXR激活与肝脏和血浆 甘油三酯 （TAG）水平降低、炎症 …
Transcriptional integration of metabolism by the nuclear sterol ...
2012年3月14日 · FXR is a central regulator of bile acid homeostasis, controlling key steps in the production and enterohepatic circulation of bile acids. FXR mediates its effects on bile...
生物X受体(farnesoid X receptor，FXR)、肝脏X受 体(liver X receptor，LXR)作为NR1亚家族中具有特 征性配体的脂质代谢调节因子，参与营养物质在 肠道的吸收、从肠道-肝脏向脂肪组织和 …
Coordinated Actions of FXR and LXR in Metabolism: From …
Here we review the recent progress concerning the physiological and pathophysiological roles of FXRs and LXRs in the regulation of bile acid, lipid and glucose metabolism and the …
核受体LXR和FXR对脂类代谢的调节（PDF） - 豆丁网
2015年7月11日 · fxr 在调控正常血浆脂蛋白水平方面所起的作用。 近年来, 大量研究发现lxr 和fxr 在胆汁酸、 胆固醇和脂蛋白合成和转运过程中起重要的调节作. 用。而胆汁酸和胆固醇代谢紊 …
Transcriptional integration of metabolism by the nuclear sterol ...
2012年3月14日 · The liver X receptors (LXRs) and the farnesoid X receptors (FXRs) are activated by oxysterols and bile acids, respectively. Mounting evidence indicates that these nuclear …
LXRS和FXR：胆固醇和脂肪代谢的阴阳。,Annual Review of …
LXR和FXR一起代表了潜在的治疗靶标，用于治疗和预防多种代谢和脂质相关疾病。 肝X受体（LXR）和法尼醇X受体（FXR）是核受体，分别充当甾醇和胆汁酸的细胞内传感器。 这些受 …
Liver X receptors in lipid signalling and membrane homeostasis
2018年6月14日 · Several nuclear receptors, including liver X receptors (LXRs; also known as oxysterols receptor LXR), farnesoid X receptors (FXRs) and peroxisome proliferator-activated …
PPAR- and LXR-dependent pathways controlling lipid metabolism …
2004年12月1日 · Regulation of cholesterol efflux pathways in macrophages by PPARs and LXRs. LXR agonists stimulate the expression of ABCA1, which facilitates the efflux of cholesterol to …