2024年12月25日 · LAMC2 (Laminin Subunit Gamma 2) is a Protein Coding gene. Diseases associated with LAMC2 include Epidermolysis Bullosa, Junctional 3A, Intermediate and Epidermolysis Bullosa, Junctional 3B, Severe. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include heparin binding.

该基因编码伽马链亚型层粘连蛋白，伽马 2。 伽马 2 链，以前被认为是 β 链 (B2t) 的截短版本，与伽马 1 链高度同源；但是，它缺少域 VI，并且域 V、IV 和 III 更短。 它在几种胎儿组织中表达，但与 γ1 不同，并且特别定位于皮肤、肺和肾中的上皮细胞。 γ 2 链与 alpha 3 和 beta 3 链一起构成层粘连蛋白 5 (以前称为 kalinin) ，它是将上皮细胞连接到下面的基底膜的锚定丝的组成部分。 γ 2 链的上皮细胞特异性表达暗示其作为上皮细胞附着分子的作用，并且该基因的突变与交界性大 …

Laminin subunit gamma-2 is a protein that in humans is encoded by the LAMC2 gene. [5] [6] Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes.

2015年1月16日 · Using genome-wide transcriptional analysis in an experimental metastasis model, we identified laminin γ 2 (LAMC2), an epithelial basement membrane protein, to be significantly upregulated in lung...

2023年3月14日 · LAMC2 inhibition impaired cell cycle, induced apoptosis, and sensitized PDAC to MEK1/2 inhibitors (MEK1/2i). A LAMC2-regulated network was featured in PDAC, including both classical and quasi-mesenchymal subtypes, and contained downstream effectors transcriptionally shared by the KRAS signaling pathway.

The LAMC2 gene provides instructions for making one part (subunit) of a protein called laminin 332 (formerly known as laminin 5). This protein is made up of three subunits, called alpha, beta, and gamma. The LAMC2 gene carries instructions for the gamma subunit; the alpha and beta subunits are produced from other genes.

目的 探讨层粘连蛋白γ2 (LAMC2)通过PI3K/ Akt 对胃癌细胞增殖的影响。 方法 利用癌症基因组图谱 (TCGA)及基因表达综合数据库 (GEO)联合分析胃癌中与细胞增殖相关差异基因,根据差异倍数确定候选基因 LAMC2=。 UALCAN 及Kaplan-Meier plotter 在线数据库分析 LAMC 2 在胃癌中的表达及其与临床病理特征的关系,采用蛋白印迹 (Western blot)法检测人胃癌细胞株 (HGC-27、NCI-N87、SNU-1)中LAMC2 的表达。 构建LAMC2敲减胃癌细胞模型,Western blot 检测LAMC2 …

2025年1月4日 · Title: LAMC2 promotes EGFR cell membrane localization and acts as a novel biomarker for tyrosine kinase inhibitors (TKIs) sensitivity in lung cancer. LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth.

2025年2月8日 · Used to study junctional epidermolysis bullosa Herlitz type and junctional epidermolysis bullosa non-Herlitz type. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to human LAMC2 (laminin subunit gamma 2). [provided by Alliance of Genome Resources, Feb 2025]

lamc2是一种细胞外基质蛋白，通过与细胞表面的高亲和力受体结合，参与调节细胞的黏附、迁移和组织形成。 其作用机制涉及与细胞外基质的其他组分相互作用，影响细胞的行为和组织结构的稳定性。