Lamins, also known as nuclear lamins, are fibrous proteins in type V intermediate filaments, providing structural function and transcriptional regulation in the cell nucleus. Nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope.

2011年12月5日 · The lamins are the major architectural proteins of the animal cell nucleus. Lamins line the inside of the nuclear membrane, where they provide a platform for the binding of proteins and chromatin and confer mechanical stability.

Laminins are a family of glycoproteins of the extracellular matrix of all animals. They are major constituents of the basement membrane, namely the basal lamina (the protein network foundation for most cells and organs). Laminins are vital to biological activity, influencing cell differentiation, migration, and adhesion. [1][2]

Lamin A/C is a nuclear protein with many functions in cells, such as maintaining a cell’s structural stability, cell motility, mechanosensing, chromosome organization, gene regulation, cell differentiation, DNA damage repair, and telomere protection.

2012年12月5日 · A comprehensive description of the roles of lamin B1 and lamin B2 in neurogenesis. Evidence is presented that B-type lamins have an essential role in neuronal migration.

Lamins are nuclear intermediate filament proteins and are the principal component of the nuclear lamina, a meshwork of proteins residing just inside the inner nuclear membrane (INM).

2024年2月1日 · The nuclear lamina (NL) is a crucial component of the inner nuclear membrane (INM) and consists of lamin filaments and associated proteins. Lamins are type V intermediate filament proteins essential for maintaining the integrity and mechanical properties of the nucleus.

Here, we provide an overview of the diverse functions of nuclear lamins and how defects in these functions – caused by mutations or altered expression – can contribute to human disease. Lamins are grouped into A-type and B-type lamins.

2019年8月21日 · Here, we present the crystal structure of a long human lamin fragment at 3.2 Å resolution that allows the visualization of the features of the full-length protein. The structure shows an...

2011年12月5日 · Lamins line the inside of the nuclear membrane, where they provide a platform for the binding of proteins and chromatin and confer mechanical stability. They have been implicated in a wide range of nuclear functions, including higher-order genome organization, chromatin regulation, transcription, DNA replication and DNA repair.