2017年1月10日 · We firstly confirmed PGRN expression in these cells and its co-localization with Lamp1, a lysosome marker (Fig. 1A and B) . Then, we investigated whether PGRN expression …

2023年11月16日 · We found that PGRN loss impairs the lysosome’s degradative capacity with increased levels of v-ATPase subunits on the lysosome membrane, increased hydrolases …

2017年5月25日 · Here, we show that PGRN facilitates neuronal uptake and lysosomal delivery of prosaposin (PSAP), the precursor of saposin peptides that are essential for lysosomal …

2013年10月10日 · PGRN was colocalized with Lamp1, a lysosomal marker, and Lamp1-positive areas in GRN-deficient (KO) mice were significantly expanded compared with wild-type (WT) …

2016年5月5日 · Using confocal microscopy and fluorescent signal intensity plots of PGRN and markers for early endosomes (Rab5), late endosomes (Rab7), trans-Golgi network (Sortilin), …

RagC and PGRN are lysosome proteins that coenrich with LAMP1 at amyloid plaques. (A) WT and 5xFAD cerebral cortices stained for RagC and LAMP showing colocalization of the two …

A significantly increased overlap of galectin-3 and LAMP1 was observed in PGRN-deficient Raw 264.7 cells compared with control cells upon LLOME treatment (Fig 10A and B). Similar …

2024年2月13日 · We immunostained with antibodies against LAMP1, a lysosome membrane protein, and TMEM119 as a homeostatic microglia marker in FTD–GRN and control-derived …

2023年2月24日 · Lysosomal proximity labeling was achieved by stable integration of ascorbate peroxidase (APEX2) enzyme onto the C terminus of LAMP1 protein in human iPSCs and …

2023年7月15日 · To better understand the role of PGRN in regulating lysosome function, this study examined how loss of GRN impacts total LAMP1 protein expression and cathepsin …