We found the value of lysosomal associated membrane proteins (LAMPs) in the diagnosis and prognosis of LGG, which helps to enhance the clinical understanding of LGG treatment and improved prognosis. We assess the role of LAMPs in LGG, via …

2023年8月18日 · We assess the role of LAMPs in LGG, via the publicly available TCGA database. We explored expression levels of LAMPs in LGG using GEPIA2, cBioPortal, and UALCAN databases. The correction of LAMPs expression levels with immune cell infiltration in LGG patient was assessed by TIMER database.

2022年4月20日 · We found that LAMP2 was significantly more highly expressed in eight human tumor types (GBM, LGG, LIHC, PAAD, PRAD, SKCM, STAD, and READ) compared with normal tumor tissues, a result consistent with those shown in Figure 10A (Figure 10B).

LAMP-2A mRNA and protein levels were significantly increased in GBM center (n = 8) in comparison with peri-tumor edema zone (PTEZ, n = 8) (p < 0.0001), while increasing trend was observed as compared with low grade glioma (LGG, n = 8).

溶酶体相关膜蛋白2（LAMP-2） 是溶酶体膜的重要组成部分。 LAMP-2通过影响免疫、 巨自噬 （MA）和 分子伴侣介导的自噬 （CMA），在溶酶体保护、维持和粘附以及肿瘤细胞转移中发挥作用 [2]。 LAMP-2的不同亚型. 在人体中，LAMP-2基因的前体mRNA会通过替代剪接生成三种9号外显子不同的mRNA， 分别编码LAMP-2A、LAMP-2B和LAMP-2C三种蛋白亚型 [3-4]。 巨自噬（MA）和分子伴侣介导的自噬（CMA）是哺乳动物中研究最深入的自噬途径，在生理和病理 …

溶酶体相关膜蛋白 2 （lysosome-associated membrane glycoprotein 2， LAMP2）是溶酶体上含量丰富的一种膜蛋白，对溶酶体结构和功能的维持均起到重要作用。 LAMP2基因突变最初被发现与一种叫做 达农病 （Danon病）的X连锁显性遗传病有关，该病以致命的肥厚性心肌病、骨骼肌病和智力残疾为临床特征，病理特征为骨骼肌、心肌和神经组织中大量自噬空泡积聚。 2000年，LAMP2敲基因成功构建，该小鼠展现出与达农病相似的特征，如自噬空泡在全身多种组织 …

2020年2月6日 · Lamp2 is a heavily glycosylated type-1 lysosomal membrane protein and an important regulator of autophagy. There are three different isoforms in humans and mice and only one isoform in rats. The human Lamp2 mutation causes Danon disease (Endo et al., 2015).

2024年12月25日 · LAMP2 (Lysosomal Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with LAMP2 include Danon Disease and Left Ventricular Noncompaction. Among its related pathways are Response to elevated platelet cytosolic Ca2+ …

We found the value of lysosomal associated membrane proteins (LAMPs) in the diagnosis and prognosis of LGG, which helps to enhance the clinical understanding of LGG treatment and improved prognosis. We assess the role of LAMPs in LGG, via …

2017年7月15日 · In summary, we identify LAMP-2 as an endocytic receptor on human MoDC that routes cargo into unusual Ag processing pathways, which reduces surface expression of Ag-derived peptides while selectively enriching Ag within immunogenic exosomes. This novel pathway has implications for the initiation of immune responses both locally and at distant sites.