2020年10月7日 · Mavrilimumab targets the GM-CSF α receptor; whereas otilimab, namilumab, and lenzilumab bind directly to GM-CSF. Lenzilumab is being studied in asthma; whereas, the other three GM-CSF inhibitors have shown efficacy in reducing disease activity and improving pain in patients with rheumatoid arthritis. 4

In patients with venous thromboembolism requiring extended anticoagulation, reduction of the direct oral anticoagulant dose did not meet the non-inferiority criteria. However, the low recurrence rates in both groups and substantial reduction of clinically relevant bleeding with the reduced dose could support this regimen as an option. Further research will be needed to identify subgroups for ...

Three randomised controlled trials published in The Lancet Rheumatology evaluate the biology, clinical eficacy, and safety of otilimab, in patients with rheumatoid arthritis1,2 and hand osteoarthritis.3 Otilimab is a monoclonal anti body that binds to and blocks granulocyte macrophage colony stimulating factor (GM CSF) from connecting with its r...

Lancet Respir Med. 2022 Mar;10(3):223-224. doi: 10.1016/S2213-2600(21)00539-7. Epub 2021 Dec 1.

Lancet Rheumatol. 2020 Nov;2 (11):e648-e650. doi: 10.1016/S2665-9913 (20)30352-0. Epub 2020 Oct 7. 1 Division of Rheumatology, Hospital for Special Surgery, New York, NY, 10021, USA.

2012年8月11日 · Findings: Carriers of the LIPG 396Ser allele (2·6% frequency) had higher HDL cholesterol (0·14 mmol/L higher, p=8×10 (-13)) but similar levels of other lipid and non-lipid risk factors for myocardial infarction compared with non-carriers.

In The Lancet Respiratory Medicine, Zelalem Temesgen and colleagues 6 report on a multicentre, placebo-controlled clinical trial of hospitalised patients with COVID-19, showing that lenzilumab, a neutralising monoclonal antibody against GM-CSF, is associated with improved survival without invasive mechanical ventilation at 28 days. Lenzilumab ...

2022年1月13日 · A systematic review of animal and human studies was conducted on genetically modified (GM) food consumption to assess its safety in terms of adverse effects/events to inform public concerns and future research.

Granulocyte-macrophage colony-stimulating factor is a potent stimulator of dendritic cell maturation. We postulated that the exploitation of the pro-immunogenic effects of radiotherapy with granulocyte-macrophage colony-stimulating factor might result in abscopal responses among patients with metastatic cancer.

2024年6月20日 · A new Series on gestational diabetes published in The Lancet calls for a greater focus on early gestational diabetes and a shift to a holistic life-course approach in how we manage the disease. The Series offers a comprehensive and inclusive analysis of the most current evidence on pathophysiology, screening, management, prevention, and long ...