Langerhans cell - Wikipedia
Langerhans cells are named after Paul Langerhans, a German physician and anatomist, who discovered the cells at the age of 21 while he was a medical student. [32] Because of their dendrite -like appearance, he mistakenly identified the cells as part of the nervous system .
Langerhans Cell - Biology Dictionary
2021年4月26日 · Langerhans cells are a type of immune cell found primarily in the epidermis that have important roles in the stimulation and suppression of the adaptive immune response. They are members of the dendritic cell family and function as antigen-presenting cells.
Langerhans Cells—Revising Their Role in Skin Pathologies
Langerhans cells (LCs) are ontogenetically tissue resident macrophages that are functionally more similar to dendritic cells (DCs). In their steady state, they are found mainly in the epidermis, and after activation, they can migrate to skin draining lymph nodes where they play the role of antigen presenting cells (APCs).
Langerhans cell - Structure, Location, Function, Anatomy
2025年1月14日 · Langerhans cells are a specialized subset of dendritic cells located primarily in the epidermis of the skin. Discovered by Paul Langerhans in 1868, these cells play a crucial role in the immune system by serving as antigen-presenting cells (APCs) that bridge innate and adaptive immunity. Their strategic location in the skin, the body’s largest organ
Langerhans Cells: Sensing the Environment in Health and Disease
Langerhans cells are, due to their location within stratified epithelia, part of the first line of defense to pathogens present in the environment. Non-activated LCs are constantly migrating to the lymph nodes to present self-antigen and establish immune tolerance in homeostatic conditions (37, 38).
Langerhans Cell Histiocytosis - Cleveland Clinic
2023年12月26日 · Langerhans cell histiocytosis is a rare disorder that occurs when a type of immune system cell called Langerhans cells build up in your child’s body. When these cells accumulate, it can cause tissue damage and tumors to form.
Pathophysiology of Langerhans cells - PMC
Langerhans cells (LCs) were first described by Paul Langerhans, in 1868, as dendritically shaped cells, which were located in the squamous epithelia of epidermis. Later on, these cells were identified in all stratified squamous epithelium of mammals.
Origin, homeostasis and function of Langerhans cells and other …
Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and...
[The role of Langerhans cells in the skin immune system]
Langerhans cells (LC) are members of the dendritic cells family, residing in the basal and suprabasal layers of the epidermis and in the epithelia of the respiratory, digestive and urogenital tracts. They specialize in antigen presentation and belong to the skin immune system (SIS).
Langerhans cell histiocytosis - Wikipedia
Langerhans cell histiocytosis (LCH) is an abnormal clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes. Symptoms range from isolated bone lesions to multisystem disease. [1]