Deep representation learning of protein-protein interaction …
2024年12月18日 · Protein-protein interaction (PPI) networks, where nodes represent proteins and edges depict myriad interactions among them, are fundamental to understanding the dynamics …
Assessment of community efforts to advance network-based
2023年3月22日 · Here, we report community efforts initiated by the International Network Medicine Consortium to benchmark the ability of 26 representative network-based methods to …
Hierarchical graph learning for protein–protein interaction
2023年2月25日 · Here we present a double-viewed hierarchical graph learning model, HIGH-PPI, to predict PPIs and extrapolate the molecular details involved. In this model, we create a …
组学数据分析实操系列 | （五）蛋白互作网络分析（STRING
蛋白互作网络，即 Protein–protein interaction (PPI) network，是描述一组蛋白间相互作用关系的分析方式。因为蛋白间的相互作用关系复杂，每一个蛋白都是一个节点，多个蛋白间的相互作用 …
Constructing multilayer PPI networks based on homologous …
2025年3月10日 · When constructing a multilayer PPI network, each species’ PPI network can be treated as an independent layer. By incorporating homologous protein relationships, interlayer …
Prediction of Protein Interactions by Structural Matching: …
PRISM predicts PPIs at the proteome scale in a computationally efficient way, which enables us to construct large PPI networks. In these networks, nodes represent proteins and edges …
SGPPI: structure-aware prediction of protein–protein interactions …
2023年1月21日 · Overview of SGPPI workflow. SGPPI uses a Siamese network architecture to represent and predict interacting proteins. By identifying the interface patches and nearby …
Protein complex prediction in large protein–protein interaction network …
2022年1月1日 · Finding the actual protein complexes from a large PPI network requires a sophisticated algorithm. The protein complexes exhibit in densely connected sub-graphs in a …
DNN-PPI: A LARGE-SCALE PREDICTION OF PROTEIN–PROTEIN INTERACTIONS BASED ...
Aiming at ensuring that PPI can be predicted effectively, we used a deep neural network (DNN) for the study of PPI prediction that is based on an amino acid sequence. We present a novel …
An Efficient Computational Model for Large-Scale Prediction of …
2021年2月26日 · The proposed model has promising predictive performances on two large-scale datasets, the PPI network dataset and GraphSAGE-PPI dataset, which have 663,954 links …