2024年12月25日 · LAT (Linker For Activation Of T Cells) is a Protein Coding gene. Diseases associated with LAT include Immunodeficiency 52 and Immune Deficiency Disease. Among its related pathways are TCR Signaling (Qiagen) and Immune response NFAT in immune response.

The Linker for activation of T cells, also known as linker of activated T cells or LAT, is a protein involved in the T-cell antigen receptor signal transduction pathway which in humans is encoded by the LAT gene. [5] Alternative splicing results in multiple …

T细胞活化连接蛋白LAT（Linker for activation of T cells）是参与T细胞活化的重要衔接蛋白，该蛋白中136位酪氨酸的缓慢磷酸化促进信号启动与转导。 成熟的T细胞能够区分免疫产生的高度多样性的T细胞抗原受体库（T-…

2021年4月3日 · Gene target information for LAT - linker for activation of T cells (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

The protein encoded by this gene is phosphorylated by ZAP-70/Syk Protein Tyrosine Kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway.

The LAT gene encodes an intracellular adaptor protein that links cell-surface receptor engagement to numerous downstream signalling events, and thereby plays an integral role in the function of cell types that express the gene, including T …

2014年7月10日 · Linker for activation of T cells (LAT) is a transmembrane adaptor protein playing a key role in the development, activation and maintenance of peripheral homeostasis of T cells....

2025年3月10日 · LAT is an integral scaffold protein of the T cell signalosome, where signaling is amplified and diversified, culminating in transcription factor activation and cytoskeletal reorganization. 27,28,29,30 To overcome inefficient LAT activation in second-generation CAR T cells, we designed a bicistronic CAR platform consisting of a second-generation ...

2024年12月25日 · LAT2 (Linker For Activation Of T Cells Family Member 2) is a Protein Coding gene. Diseases associated with LAT2 include Williams-Beuren Syndrome and Hernia, Hiatus. Among its related pathways are Innate Immune System and B Cell Receptor Signaling Pathway. Gene Ontology (GO) annotations related to this gene include SH2 domain binding.

2024年3月1日 · Summary The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins.