3 天之前 · 2019年3月14日，西湖大学生物学研究所周强研究员团队在Nature发表了题为Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex的论文（第一单位为清华大学），该研究利用冷冻电镜技术，研究者首次解析了人源LAT1–4F2hc复合体整体分辨率3.3Å的 …

Like all members of the heteromeric amino acid transporter (HAT, SLC7) family, LAT1 resides in the plasma membrane in a heterodimeric form. The LAT1 holotransporter consists of a 55-kDa light chain, SCL7A5 (LAT1 proper), and an escort protein called the heavy chain covalently linked to the light chain via a disulfide bond.

4 天之前 · Heteromeric amino acid transporters (HATs), including y + LAT1-4F2hc complex, are responsible for transporting amino acids across membranes, and mutations in y + LAT1 cause lysinuric protein intolerance (LPI), a hereditary disorder characterized by defective cationic amino acid transport. The relationship between LPI and specific mutations in y …

The HAT 4F2hc-LAT1 is found upregulated in various cancer cell types, while 4F2hc-LAT2 is a transporter for non-cancer cells. Preclinical studies have highlighted that 4F2hc-LAT1 plays an important role in tumor progression representing a valid anticancer target.

Due to the significant up-regulation of LAT1 expression in several human tumors, LAT1 has been an attractive transporter for targeted delivery of amino acid-derived anticancer drugs and prodrugs as well as positron emission tomography (PET) probes for cancer diagnosis.

2021年3月23日 · LAT1 (SLC7A5) is one of the representative light chain proteins of heteromeric amino acid transporters, forming a heterodimer with its heavy chain partner 4F2hc (SLC3A2). LAT1 is overexpressed...

LAT1 (also known as SLC7A5), is defined as a heteromeric amino acid transporter (HAT) interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide to uptake not only large neutral amino acids, but also several pharmaceutical drugs to cells.

2019年7月7日 · Among the solute carriers, heteromeric amino-acid transporters (HATs) are unique in their quaternary structure. LAT1–CD98hc, a HAT, transports essential amino acids and drugs across the blood–brain barrier and into cancer cells. It is therefore an important target both biologically and therapeutically.

3 天之前 · HATs家族由轻链和重链组成，通过二硫键连接，能够运输氨基酸、多胺和药物等物质。y + LAT1-4F2hc复合体是HATs家族的典型成员，其轻链y + LAT1负责底物特异性和运输活性，重链4F2hc则作为调节亚基，对转运蛋白的功能至关重要。该复合体在肾脏和肠道上皮细胞的基 ...

L-type amino acid transporter-1 （LAT1） is a member of the sodium-independent amino acid transport system L and transports large branched-chain and aromatic neutral amino acids. LATI is normally expressed in fetal liver, bone marrow, brain, placenta, and testes.