Long-term potentiation (LTP) is a persistent increase in synaptic strength following high-frequency stimulation of a chemical synapse. Studies of LTP are often carried out in slices of the hippocampus, an important organ for learning and memory. In such studies, electrical recordings are made from cells and plotted in a graph such as this one.

LTP is the most intensively studied cellular model of the memory and generally divided at least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates biochemical events and trafficking of proteins, which eventually potentiate synaptic transmission, and is independ …

2021年6月21日 · 我们回到LTP现象来，LTP现象可以被分为早期阶段Early-LTP（E-LTP）和后期阶段Late-LTP（L-LTP）。 在E-LTP阶段，所涉及的反应机制响应比较快速，没有新蛋白合成、基因转录等慢过程。 这个过程可以使突触效能增强维持1-3小时。 这个阶段的主要反应机制是：高浓度的钙离子流入后，与钙调蛋白（Calmodulin，简称CaM）结合形成Ca2+/CaM结合体，Ca2+/CaM进而激活钙调蛋白激酶（CaMKII），并且激活的CaMKII可以维持一段时间才失 …

利用4串或更多的刺激产生的LTP可以维持超过24小时，这被称为Late-LTP (L-LTP)。 L-LTP需要cAMP，PKA以及基因转录、新蛋白质的合称来实现。 具体通路如下图（蓝色箭头）。

2021年10月20日 · 海马脑区的 长时程增强（ long-term potentiation ，LTP）是研究最多的一类突触可塑性，同时也被认为是学习记忆的一种细胞机制【1 】。 LTP根据其维持时间的长短可分为早期 LTP（E-LTP ）和晚期LTP（L-LTP ），E-LTP 由单次高频刺激（HFS ）诱导，维持时间约为1小时【2 】，L-LTP 由多次高频刺激诱导，维持时间超过1小时【3】。 尽管在过去的20 多年里，研究者们对LTP 的分子机制进行了大量研究，然而其细胞机制仍不清楚。 突触可塑性的表 …

長期增強作用（英語： Long-term potentiation ，LTP）又稱长时程增强作用、長期增益效應，是由于同步刺激两个神经元而发生在两个神经元信号传输中的一种持久的增强现象。

2018年12月6日 · LTP is the most intensively studied cellular model of the memory and generally divided at least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates biochemical events and trafficking of proteins, which eventually potentiate synaptic transmission, and is independent of de novo protein synthesis.

Long-term potentiation (LTP) is defined as a long-lasting increase in the magnitude of the synaptic response of a neuron following a short train of high-frequency afferent...

Brain-derived neurotrophic factor (BDNF) has emerged as a regulator of stable, late phase long-term potentiation (L-LTP) at excitatory glutamatergic synapses in the adult brain. However, the mechanisms by which BDNF triggers L-LTP are controversial.

Our review focuses on the mechanisms which enable the late maintenance of hippocampal long-term potentiation (LTP; >3h), a phenomenon which is thought to underlie prolonged memory. About 20 years ago we showed for the first time that the maintenance of LTP - like memory storage--depends on intact …