Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3) is a protein that in humans is encoded by the MAP1LC3B gene. [5] LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis. LC3 is the most widely used marker of autophagosomes. [6]

Microtubule-associated protein 1A/1B-light chain 3 (LC3) is a soluble protein with a molecular mass of approximately 17 kDa that is distributed ubiquitously in mammalian tissues and cultured cells. During autophagy, autophagosomes engulf cytoplasmic components, including cytosolic proteins and organ …

LC3蛋白（也称为 Microtubule-associated protein 1 light chain 3 ）是一种与细胞自噬相关的蛋白质，在细胞自噬的过程中发挥重要的作用。通过检测LC3蛋白的表达水平和形态变化，可以研究细胞自噬的活性和调控机制。

In this review, we discuss the current knowledge and functions of the LC3/GABARAP family proteins. We focus on processing of the individual family proteins and their role in autophagy initiation, cargo recognition, vesicle closure, and trafficking, a complex and tightly regulated process that requires selective presentation and recruitment of ...

2025年2月1日 · LC3B, a member of the LC3/GABARAP family, is a ubiquitin-like protein that orchestrates autophagy alongside phosphatidylethanolamine (PE) through a series of E1-E2-E3 conjugation reactions. This process suggests an intersection with the ubiquitin-proteasome system, where LC3B levels are modulated through ubiquitination and subsequent ...

2025年2月4日 · The subsequent signaling cascade promotes the conjugation of phosphatidylethanolamine (PE) to microtubule-associated protein 1 A/1B-light chain 3 (LC3), a key component that forms...

2019年7月12日 · The lipidated LC3, known as LC3-II, has a faster mobility than LC3-I on SDS PAGE and is relatively specifically associated with autophagosomes and autolysosomes (in the absence of conditions...

2022年3月17日 · Here, we show that LC3B is an RNA-binding protein that directly binds to mRNAs with a preference for a consensus AAUAAA motif corresponding to a polyadenylation sequence.

2015年9月17日 · LC3s (MAP1-LC3A, B and C) are structural proteins of autophagosomal membranes, widely used as biomarkers of autophagy. Whether these three LC3 proteins have a similar biological role in autophagy remains obscure.

LC3蛋白（也称为Microtubule-associated protein 1 light chain 3）是一种与细胞自噬相关的蛋白质，在细胞自噬的过程中发挥重要的作用。 通过检测LC3蛋白的表达水平和形态变化，可以研究细胞自噬的活性和调控机制。