2017年10月23日 · Here we show that LCK regulates the function of the type III receptor tyrosine kinase FLT3 in murine pro-B cells. We observed that expression of LCK significantly enhances the colony forming...

Using Ba/F3 cells lacking endogenous Lck as a murine model for AML, it was shown that ectopic expression of Lck significantly enhanced the colony forming capacity of the FLT3-ITD mutant, but it had no effect on the survival or apoptosis of Ba/F3 cells transfected with FLT3 WT.

2012年7月13日 · We identified F621L, A627P, F691L and Y842C mutations in FLT3/ITD that confer varying levels of resistance to FLT3 TKI. Western blotting confirmed that some FLT3 TKI were ineffective at...

2019年2月1日 · Binding of its ligand, FLT3 ligand (FL), induces dimerization and activation of its intrinsic tyrosine kinase activity. This leads to autophosphorylation of FLT3 on several tyrosine residues which constitute high affinity binding sites for signal transduction molecules.

2017年10月23日 · Here we show that LCK regulates the function of the type III receptor tyrosine kinase FLT3 in murine pro-B cells. We observed that expression of LCK significantly enhances the colony forming capacity of the constitutively active …

苯磺酸克立福替尼片（hec73543）是新一代、高特异性的flt3抑制剂，可以阻断flt3-itd突变引起的flt3信号通路持续活化，从而抑制aml细胞的无限增殖及抗凋亡作用，最终达到治疗aml的效果。

2017年10月23日 · Here we show that LCK regulates the function of the type III receptor tyrosine kinase FLT3 in murine pro-B cells. We observed that expression of LCK significantly enhances the colony forming...

Using Ba/F3 cells lacking endogenous Lck as a murine model for AML, it was shown that ectopic expression of Lck significantly enhanced the colony forming capacity of the FLT3-ITD mutant, but...

2005年4月22日 · Herein, we provide compelling evidence for a novel route for early blood lineage commitment and development, in that LSK Flt3 + cells, although sustaining a high proliferative and combined lympho-myeloid differentiation potential, have lost the ability to significantly adapt Mk and E lineage fates and in agreement with this downregulate expressi...

There is increasing evidence that the T-cell protein, Lck, is involved in the pathogenesis of chronic lymphocytic leukemia (CLL) as well as other leukemias and lymphomas. We previously discovered that Lck binds to domain 5 of inositol 1,4,5-trisphosphate receptors (IP₃R) to regulate Ca …