The phosphatidylinositol 3-kinase (PI3K) and the tyrosine phosphatase SHP-1 are two Lck substrates that have been implicated in TCR signaling. In this study, we demonstrate that SHP …

SHP-1 localization to lipid rafts and its effect on T-cell signaling. The importance of the subcellular localization of signaling molecules during TCR activation has been re-emphasized recently. In …

2024年3月27日 · TRAIL engagement significantly reduced Lck (Y394) phosphorylation in the activated T cells along with the increased phosphorylated SHP-1 in the TRAIL-R/SHP-1/Lck …

2013年1月21日 · SHP-1 作为 PTP 中重要的一员，是改变胞内磷酸化水平的关键因子，当外源性信号分子同胞膜上受体结合后激发受体分子二聚化，与受体耦联的两面神激酶（JAK）互相靠 …

2014年12月22日 · Mass spectrometry‐based interactomics identifies the protein tyrosine phosphatases SHP 1 and SHP 2 and the adapter protein GRB 2 as major binding partners in …

The inhibitory effect of KIR ligation requires the phosphotyrosine-dependent association of KIR with the cytoplasmic SH2-containing protein tyrosine phosphatase SHP-1. Using a somatic …

The tyrosine phosphatase SHP-1 is a key player in the downregulation of LCK activation. In this review, we focus on the crosstalk between LCK and SHP-1 and, based on recent data, we …

2020年2月10日 · We found that LCK recruited into the synapse of CD28-encoding CAR by co-receptors causes antigen-independent CAR-CD3ζ phosphorylation and increased antigen …

In this study, we demonstrate that Lck activity is associated with an interaction of SHP-1 with the p85 subunit of PI3K, and also identify p85 as a target for SHP-1-mediated dephospho-rylation.

2024年3月27日 · TRAIL-R associates with phosphatase SHP-1 and transduces a unique and distinct immune gatekeeper signal to repress TCR signaling and T cell activation via …