Lck, a member of the Src kinase family, is a non-receptor tyrosine kinase involved in immune cell activation, antigen recognition, tumor growth, and cytotoxic response. The enzyme has usually been linked to T lymphocyte activation upon antigen recognition. Lck activation is central to CD4, CD8, and NK activation.

共受体分子如CD4/CD8被报道可以结合LCK（coreceptor-associated LCK），促进LCK激活。 然而，CD4/CD8的缺失并不阻碍T细胞的发育活化，只影响MHC特异性的T细胞识别，提示LCK的激活还存在其它调控形式。

In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck-deficient T-cell lines have shown that Lck regulates the initiation of TCR signaling, T …

2021年6月11日 · Integrative gene expression analysis identified the Lymphocyte cell-specific protein-tyrosine kinase (LCK) as a druggable target gene associated with cancer cell invasion and metastasis. Inhibition of LCK using A-770041 or dasatinib blocked invasion of …

2022年12月23日 · Overall, our findings reveal the role of co-receptor-bound LCK in T cell biology, show that CD4- and CD8-bound LCK drive T cell development and effector immune responses using qualitatively...

2024年7月24日 · Lck, a member of the Src kinase family, is a non-receptor tyrosine kinase involved in immune cell activation, antigen recognition, tumor growth, and cytotoxic response. The enzyme has usually been linked to T lymphocyte activation upon antigen recognition. Lck activation is central to CD4, CD8, and …

2022年11月13日 · In this study, pan-cancer analysis based on a variety of databases was used to explore the role of LCK in human tumors, including their occurrence, development, progression, and potential signaling pathways (Figure 1). In particular, we explored the differential expression of LCK in TCGA tumors.

2019年7月16日 · In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck-deficient T-cell lines have shown that Lck regulates the initiation of TCR signaling, T-cell development, and T-cell hom …

2018年12月1日 · Lck is an essential early mediator of the TCR signaling pathway. Lck, a non-receptor src family kinase, plays a vital role in various cellular processes such as cell cycle control, cell adhesion, motility, proliferation and differentiation.

2024年7月24日 · In colorectal cancer, Lck is expressed in some human colon carcinoma cell lines and is found at low levels in normal colonic epithelial cells, with its upregulation potentially leading to tumorigenesis. Lck inhibitors are therefore considered a promising strategy for treating colorectal cancer.