2019年3月28日 · The virus mainly infects B lymphocytes and could immortalize and transform the cells into EBV-bearing lymphoblastoid cell lines (LCLs). Limited studies have been focused on characterizing the surface marker expression of the immortalized LCLs.

2017年3月8日 · Lymphoblastoid cell lines (LCLs) transformed by Epstein-Barr virus (EBV) serve as an unlimited resource of human genomic DNA. The protocol that is widely used to...

In this study, we demonstrated that EBV could efficiently immortalize B-cells from RA patients' peripheral blood and form LCLs. We then examined the expression levels of several B-cells subpopulation markers including CD23 and CD27 in both LCLs and their parental B-cells.

2023年3月22日 · Epstein-Barr virus (EBV) immortalization of resting B lymphocytes (RBLs) to lymphoblastoid cell lines (LCLs) models human DNA tumor virus oncogenesis. RBL and LCL chromatin interaction...

Epstein-Barr virus (EBV) is a lymphotropic γ herpes virus. Infection of human B cells with EBV in vitro results in their immortalization and the resulting cell lines are named lymphoblastoid cell lines (LCLs) (1). In these cells, EBV establishes mainly a latent infection, characterized by the expression of a limited number of viral proteins.

2011年11月8日 · Infection of B cells with Epstein-Barr virus (EBV) leads to proliferation and subsequent immortalization, resulting in establishment of lymphoblastoid cell lines (LCL) in vitro. Since LCL are latently infected with EBV, they provide a model system to investigate EBV latency and virus-driven B cell p …

人外周血B细胞来源于骨髓,是异质性的.EB病毒 (Epstein-Barr virus,EBV)可在体外感染静止B细胞 (naive B cells),利用其潜伏基因表达产物改变B细胞生命周期,从而形成永生化B淋巴母细胞系 (B lymphoblastoid cell lines,B-LCLs),是近年来常用的B细胞永生化的有效方法.B-LCLs常被用作外周 ...

Lymphoblastoid cell lines (LCLs) can be generated easily by in vitro EBV infection of B lymphocytes collected from any individual. In vitro, these EBV-infected B cell cultures yield proliferating, transformed lines referred to as lymphoblastoid cell lines (LCLs).

EB 病毒是一种嗜人B 细胞的疤疹病毒,在体外感染B 细胞使之成为永生细胞系,可在免疫缺陷小鼠体内诱发淋巴瘤。EBV对人类细胞具有较强的致瘤性, 与HD、NPC、BL 及AIDS 的关系非常密切,建立EBV-LCLs 肿瘤模型, 对EBV的致瘤机理的研究非常重要[14]。

人外周血B细胞来源于骨髓,是异质性的.EB病毒 (Epstein-Barr virus,EBV)可在体外感染静止B细胞 (naive B cells),利用其潜伏基因表达产物改变B细胞生命周期,从而形成永生化B淋巴母细胞系 (B lymphoblastoid cell lines,B-LCLs),是近年来常用的B细胞永生化的有效方法.B-LCLs常被用作外周 ...