LDLR is a cell membrane glycoprotein that functions in the binding and internalizing of circulating cholesterol-containing lipoprotein particles. LDLR is ubiquitously expressed and is a key …

The LDLR gene provides instructions for making a protein called the low-density lipoprotein receptor. This receptor binds to particles called low-density lipoproteins (LDLs), which are the …

Dec 25, 2024 · The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is …

LDLR, VLDLR, and LRPs bind and internalize apoE- and apoB-containing lipoprotein, including LDL and VLDL, and regulate their cellular uptake. LRP6 is a unique member of this family for …

Mar 12, 2025 · LDLR (low-density lipoprotein receptor) is a long-lived type 1 transmembrane protein that undergoes multiple rounds of internalization and recycling between the cell surface …

Low-density lipoprotein (LDL) internalization, degradation, and receptor recycling is a fundamental process underlying hypercholesterolemia, a high blood cholesterol concentration, affecting …

Low density lipoprotein receptor (LDLR) is responsible for uptake of cholesterol-carrying lipoprotein particles into cells. The receptor binds lipoprotein particles at the cell surface and …

Jun 5, 2023 · This intracellular transport pathway of LDL–LDLR bypasses the lysosomes and delivers cholesterol to the mitochondria for steroidogenesis.

Jan 4, 2025 · The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is …

Aug 19, 2019 · HGNC Approved Gene Symbol: LDLR. Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38) : 19:11,089,463-11,133,820 (from NCBI) The low density lipoprotein …