Cholesterol-Lowering Gene Therapy Counteracts the Development …
2017年11月1日 · AAV8 -LDLr gene therapy attenuated cardiac hypertrophy, reduced interstitial and perivascular fibrosis, and decreased lung congestion in TAC mice.
A covalent peptide-based lysosome-targeting protein ... - Nature
2025年2月6日 · Biological experiments demonstrate that covalent Pep-TACs can significantly degrade the expression of PD-L1 on tumor cells, dendritic cells and macrophages, especially under acidic conditions, and...
Cholesterol lowering attenuates pressure overload-induced heart …
2019年9月9日 · The principal findings of the current study are that (1) cholesterol lowering gene therapy in C57BL/6 LDLr-/-mice with only mild hypercholesterolemia significantly decreased mortality after TAC; (2) AAV8-LDLr gene transfer attenuated left ventricular hypertrophy, potently decreased interstitial myocardial fibrosis and perivascular myocardial ...
Cholesterol-Lowering Gene Therapy Counteracts the Development …
2017年11月1日 · AAV8-LDLr gene therapy attenuated cardiac hypertrophy, reduced interstitial and perivascular fibrosis, and decreased lung congestion in TAC mice. Cardiac function, quantified by invasive hemodynamic measurements and magnetic resonance imaging, was significantly improved 8 weeks after sham operation or …
Mouse models of atherosclerosis and their suitability for the study …
The types and locations of lesions in LDLR −/− mice are similar to ApoE −/− mice, and build up gradually with the earliest lesions seen in the proximal aorta. In general, the LDLR −/− model is a milder model of atherosclerosis than the ApoE −/− mice mainly due to the lower hyperlipidaemia observed [21, 184].
基于共价肽的肿瘤免疫治疗溶酶体靶向蛋白降解平台 - 生物通
2025年2月7日 · 为了扩充有限的用于 TPD 的溶酶体穿梭受体库，研究人员利用癌症基因组图谱（TCGA）的数据，检测并比较了多种溶酶体靶向受体（LTRs），包括甘露糖 - 6 - 磷酸受体（M6PR）、去唾液酸糖蛋白受体（ASGPR）、低密度脂蛋白受体（LDLR）、转铁蛋白受体（TFRC）、整合素 αV（ITGAV）、叶酸受体 1（FOLR1）和表皮生长因子受体（EGFR）在结肠癌、黑色素瘤、胶质瘤和乳腺癌中的表达谱。 结果表明，在上述肿瘤中，TFRC 的表达水平 …
Total and non-HDL, VLDL, IDL, LDL, and HDL plasma cholesterol …
In this study, our aim was to quantify coronary atherosclerosis and artery remodeling following transverse aortic constriction (TAC) in C57BL/6N apo E−/− mice and to evaluate the impact of...
Representative Sirius red-stained cross-sections of non …
The objective of the current study was to evaluate the effect of selective cholesterol lowering adeno-associated viral serotype 8 (AAV8)-mediated low-density lipoprotein receptor (LDLr) gene ...
Cholesterol lowering attenuates pressure overload-induced heart …
2019年9月4日 · Cholesterol lowering gene therapy counteracted myocardial oxidative stress and preserved the potential for myocardial fatty acid oxidation in TAC mice. In conclusion, cholesterol lowering...
金合欢素的降血脂及抗动脉粥样硬化作用及机制初探
降低ldl-c是目前临床治疗动脉粥样硬化性心血管病的主要干预靶点, 他汀类药物就是反馈上调细胞表面ldlr, 使血浆胆固醇水平降低。在前期研究中, 本课题组发现田蓟苷作用动脉粥样硬化模型大鼠12周后, 血清中tc、tg及ldl-c水平较模型组均显著降低 。金合欢素是田 ...