The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. The protein is highly glycosylated through N- and O-linkages and thus migrates at 100 to 160 kDa bands on SDS-PAGE.

2019年8月6日 · These data suggested that a proteolytic cleavage event occurs in the extracellular ligand binding domain of the full-length 160 kDa LDLR, generating a 36–40 kDa soluble NTF and a 120 kDa...

2024年7月23日 · Like other secretory and endomembrane proteins, nascent LDLR is initially synthesized in the ER as an immature protein with a molecular weight of ∼120 KDa and is post-translationally modified by N- and O-glycosylation in the ER and the Golgi apparatus increasing its apparent molecular weight from ∼120 KDa to ∼160 KDa .

2013年6月1日 · Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the LDL receptor (LDLR) at the cell surface and reroutes the internalized LDLR to intracellular degradation. In this study, we have shown that PCSK9-mediated degradation of the full-length 160 kDa LDLR generates a 17 kDa C-terminal LDLR fragment.

LDLR Protein, Mouse (HEK293, His) is the recombinant mouse-derived LDLR protein, expressed by HEK293 , with C-His labeled tag. The total length of LDLR Protein, Mouse (HEK293, His) is 769 a.a., with molecular weight of ~98-130 kDa. LDLR 蛋白在与 LDL 结合方面发挥着至关重要的作用，LDL 是负责在血液中运输胆固醇的主要脂蛋白，并通过内吞作用促进其内化到细胞中。 为了进行内化，受体-配体复合物必须首先聚集成网格蛋白包被的凹坑。

Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the LDL receptor (LDLR) at the cell surface and reroutes the internalized LDLR to intracellular degradation. In this study, we have shown that PCSK9-mediated degradation of the full-length 160 kDa LDLR generates a 17 kDa C-terminal LDLR …

2012年1月1日 · Western blot analysis of transfected cells indicated that the truncated form (∆N-LDLR) is a degradation product of the full-length LDLR generated by cleavage in the linker region between ligand-binding repeats 4 and 5 of the ligand-binding domain.

Invitrogen Anti-LDLR Polyclonal, Catalog # PA5-22976. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF) and Immunohistochemistry (Paraffin) (IHC (P)) applications. This antibody reacts with Human, Mouse samples.