LDLR 蛋白, Human (HEK293, His) | MCE - MCE-生物活性分子大师
In microbial infection, LDLR acts as a receptor for hepatitis C virus in hepatocytes, emphasizing its dual functionality in cholesterol metabolism and the cellular response to viral infections. LDLR Protein, Human (HEK293, His) is the recombinant human-derived LDLR protein, expressed by HEK293, with C-6*His labeled tag.
Structural basis for the recognition of LDL-receptor family
2018年3月12日 · Low-density lipoprotein receptor (LDL-R) serves as a major entry receptor for VSV. Here we report two crystal structures of VSV G in complex with two distinct cysteine-rich...
Identification of global inhibitors of cellular glycosylation
2023年2月20日 · First, a secreted 6xHis-tagged chimeric CFP-LDLR reporter was designed for stable expression in HEK293 SimpleCells (SC) (HEK KO COSMC), which endogenously express GALNT11 and secrete the...
Expression of human LDLR in HEK-293T cells. (a) Scheme of LDLR …
To explore the siRNA approach, we transfected LDLR siRNA to decrease the endogenous expression of LDLR in A549 human lung epithelial cells ( Figure S3). By comparison of particle uptake between...
Functional Characterization of Two Low-Density Lipoprotein …
2014年3月26日 · Familial hypercholesterolemia (FH) is an autosomal dominant disease that primarily results from mutations in the low-density lipoprotein receptor ( LDLR) gene. We investigated two unrelated Chinese FH patients using gene screening and functional analysis to reveal the pathogenicity and the mechanism by which these mutations cause FH.
Human LDLR Knockout Cell Line-HEK293T - Creative Biogene
In this study, researchers identified two host restriction factors that hinder LV production in HEK293T packaging cells, 2′-5′-oligoadenylate synthetase 1 (OAS1) and low-density lipoprotein receptor (LDLR). Knockout of these two genes individually resulted in an approximately 2-fold increase in viral titers.
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LXR Regulates Cholesterol Uptake Through Idol-Dependent ... - Science
2009年6月11日 · Idol knockdown in hepatocytes increases LDLR protein levels and promotes LDL uptake. Conversely, adenovirus-mediated expression of Idol in mouse liver promotes LDLR degradation and elevates plasma LDL levels.
Exosome-based Ldlr gene therapy for familial …
2021年1月1日 · Using the Ldlr-/-mouse model, we found that exosomes-mediated Ldlr mRNA delivery could robustly restore LDLR expression and thus reverse the phenotype, such as steatosis, high LDL cholesterol, and atherosclerosis. The study has offered a new therapeutic approach as an alternative to the viral vectors for the treatment of FH patients.
Expression of Recombinant LDLR–EGFP Fusion Protein in HEK
2018年4月14日 · Confocal microscopy has shown that, upon transient transfection of HEK293 cells with the plasmid, the recombinant fusion protein LDLR–EGFP is transported onto the cellular membrane and binds labeled LDL.
LDLR - 百度百科
ldlr，低密度脂蛋白受体相关蛋白是近年来发现的一种细胞表面蛋白,属于一种内吞性受体,系低密度脂蛋白受体基因家族中的一员.由于其能够与多种结构及功能各异的配体相互作用,不仅可以对血脂的动态平衡及纤溶功能的稳定进行调节,而且能参与多种生长因子 ...