Here, we reinvestigated the role of the LDLR in the HCV life cycle by comparing virus entry to the mechanism of lipoprotein uptake. A small interfering RNA targeting the LDLR in Huh-7 cells …

2014年3月1日 · We demonstrate that HCV stimulates LDLR expression in both HCV-infected Huh7 cells and in liver tissue from chronic hepatitis C patients. Fluorescence activated cell …

Intracellular amounts of replicative and genomic HCV RNA strands used as end point of infection were assessed by RT-PCR. Results: r-shLDLR4-292, antibodies against r-shLDLR4-292 and …

Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and …

结果：在Huh-7细胞中一个针对LDLR的小型干扰RNA可降低HCV的感染性，证实了LDLR在HCV的细胞培养增殖周期中的作用. 然而脂蛋白的内化动力学比具有感染性的 HCV颗粒的内化快得多 …

2021年6月29日 · We found that individual ablation of the lipoprotein receptors SR-B1 and LDLr did not drastically affect HCV entry, replication, or infection, but double lipoprotein receptor …

Scavenger receptor class B type 1 (SR-B1) and low-density lipoprotein receptor (LDLR) are known to be involved in entry of hepatitis C virus (HCV), but their precise roles and their …

2021年6月29日 · We found that individual ablation of the lipoprotein receptors SR‑B1 and LDLr did not drastically affect HCV entry, replication, or infection, but double lipoprotein receptor …

While CM and VLDL are triglyceride-rich lipoproteins (TRL), LDL and HDL contain high cholesterol levels. Lipoprotein density depends on their lipid and protein composition. Thus, …

2016年2月2日 · Following the initial binding of hepatitis C virus (HCV) to glycosaminoglycans present on heparan sulfate proteoglycans (HSPGs), to low-density lipoprotein receptor …