Lead-DBS: A toolbox facilitating Deep Brain Stimulation electrode reconstruction and computer simulation based on postoperative MRI & CT imaging. Download Lead-DBS Watch the walkthrough tutorial

Atlas including STN, pallidum and red nucleus made on 7T data from 12 healthy controls. The templates on which the atlas is defined is not in MNI space but can be used within Lead-DBS for normalizations, as well (instead of using an MNI template). Also, there is an MNI version ported from template to MNI space available within Lead-DBS.

2023年3月1日 · Lead-DBS v3.0 features an end-to-end solution for DBS-based neuroimaging analysis. New preprocessing tools include WarpDrive and algorithms for electrode localization. Three novel tools allow mapping of DBS effects to local, tract and network level. Lead-DBS v3.0 features pathway activation modeling.

2015年2月15日 · To determine placement of electrodes after deep brain stimulation (DBS) surgery, a novel toolbox that facilitates both reconstruction of the lead electrode trajectory and the contact placement is introduced.

2022年1月1日 · Lead-DBS location of the limbic STN was in agreement with electrophysiological markers. Phase duration and firing rates could help identify dopamine neurons in humans. Microelectrode recordings (MERs) are often used during deep brain stimulation (DBS) surgeries to confirm the position of electrodes in patients with advanced Parkinson’s disease.

皮层下核团图谱能够显示出dbs靶点如丘脑底核（stn）和苍白球内侧部（gpi），这些核团在临床使用的普通mri序列上是不能完美显示的。 一个常见的需求就是确定植入电极与靶点的空间关系，并探索电极位置与治疗结果的相关性。

脑深部电刺激（deep brain stimulation，DBS）利用立体定向神经外科技术，将刺 激电极置入到脑深部核团，并且提供持续的电刺激， 能够明显改善震颤、僵直等运动症状，提高帕金森病 患者的生活质量。位于脑深部的丘脑底核 （subthalamic nucleus，STN）为DBS 治疗最重要 ...

Lead-DBS is an open-source, MATLAB-based toolbox to localize and visualize electrodes in patients treated with deep brain stimulation. Importantly, the toolbox is intended for research and not for clinical use.

2023年2月23日 · 我们纳入了 26 名接受底丘脑核 (STN)-DBS 治疗的患者（21 名患有帕金森病，5 名患有肌张力障碍），并使用 Lead-DBS 工具箱和 Surgiplan 重建了 DBS 电极。 通过术后 CT 和 MRI 比较了 Lead-DBS 和 Surgiplan 之间的电极接触坐标。

Bilateral subthalamic nucleus (STN) Deep brain stimulation (DBS) is a well-established treatment in patients with Parkinson’s disease (PD). Traditionally, STN DBS for PD is performed by using microelectrode recording (MER) and/or intraoperative macrostimulation under local …