Lead was associated with increased FSH means of 8.0% (95% CI, –0.9% to 17.7%) for the middle tertile and 3.6% (95% CI, –5.3% to 13.3%) for the upper tertile, compared with the lowest. Mercury was associated with a change in LH for the middle tertile of –11.7% (95% CI, –20.0% to –2.5%) compared with the lowest.

Although evidence is conflicting, it has been reported that accumulation of lead affects the majority of the endocrine glands. In particular, it appears to have an effect on the hypothalamic-pituitary axis causing blunted TSH, GH, and FSH/LH responses to TRH, GHRH, and GnRH stimulation, respectively.

2019年8月28日 · Multiple linear regression analysis was used to determine the relationship between the blood levels of lead and mercury and the urine cadmium level, and serum FSH levels. Results: On multiple linear regression analysis, lead exposure was positively associated with serum FSH concentrations in postmenopausal women (β = 2.929, p = 0.019).

Increased concentrations of other reproductive hormones, such as follicle stimulation hormone (FSH), secreted from the pituitary gland, have been observed following lead exposure in men and in lead treated rats .

2007年7月1日 · In the present study, the NHANES III data are used to assess the relationships between blood lead levels and the concentrations of serum FSH and LH in women, 35–60 years old. Increases in FSH and LH concentrations may indicate that a woman's ovaries are not functioning well.

It appears to have an effect on the hypothalamic–pituitary axis causing blunted thyroid-stimulating hormone, growth hormone, and follicle-stimulating hormone (FSH)/luteinizing hormone (LH) responses to thyrotropin-releasing hormone, growth hormone–releasing hormone, and gonadotropin-releasing hormone stimulation, respectively.

Methods: Among 252 premenopausal women aged 18-44 years, we examined the association between blood metal levels (cadmium, lead and mercury), cycle length, and reproductive hormones [FSH, LH, estradiol (E (2)) and progesterone] measured at clinically relevant time points in the menstrual cycle.

Follicle-stimulating hormone (FSH), a gonadotropin secreted by the pituitary gland, is a representative secondary sex hormone and an important indicator of reproductive function. The effects of heavy metals such as lead, cadmium, and mercury on humans have been studied, but reports on their effects on sex hormone levels are lacking.

2019年8月28日 · Results: On multiple linear regression analysis, lead exposure was positively associated with serum FSH concentrations in postmenopausal women (β = 2.929, p = 0.019). However, we found no...

2013年6月1日 · Zhou et al. exposed the support cell matrix to the lead acetate, finding that lead could restrain the FSH from binding with its receptor and cause the FSH level to increase with lead concentration rising. Yu et al. discovered that lead could inhibit inhibin B from secreting. Inhibin B had negative feedback effects on FSH and LH levels [29] .