2023年1月31日 · We demonstrate that glutamatergic LEC inputs can drive local dendritic spikes in CA1 pyramidal neurons, aided by the recruitment of a disinhibitory VIP interneuron microcircuit. Our circuit mapping and modeling further reveal that LEC inputs also recruit CCK interneurons that may act as strong suppressors of dendritic spikes.

2017年3月6日 · Here we report that lateral EC projection neurons selectively form direct excitatory synapses onto a subpopulation of morphologically complex, calbindin-expressing pyramidal cells (PCs) in the...

2023年10月9日 · Here, we exploit in vivo sub-cellular imaging to record from EC axons in CA1 while mice perform navigational tasks in virtual reality (VR). We uncover distinct yet overlapping representations of task, location, and context in both MEC and LEC axons.

2023年5月31日 · In this study, we investigated the neural representation features of two distinct learning-related behavioral events in the entorhinal-hippocampal-entorhinal pathway, CA1, and superficial and...

The topographic organization of LEC and MEC inputs suggests that neurons in proximal or distal CA1 receive predominantly one set of entorhinal–cortical inputs via the TA pathway, implying the existence of functional division along the transverse axis of area CA1.

2017年1月3日 · We demonstrate that the two inputs differentially activate the radial sublayers and that this difference reverses along the transverse axis, with MEC preferentially targeting deep PNs in proximal CA1 and LEC preferentially exciting superficial PNs in distal CA1.

Here, we exploit sub-cellular imaging to record in vivo from EC axons in CA1 while mice perform navigational tasks in virtual reality (VR). We uncover distinct yet overlapping representations of task, location, and context in both MEC and LEC axons.

Here, we exploit in vivo sub-cellular imaging to record from EC axons in CA1, while mice perform navigational tasks in virtual reality. We uncover distinct yet overlapping representations of task, location, and context in both MEC and LEC axons.

2017年3月18日 · 最近来自国内的科学家发现了直接通路，即从L EC的layer 3 →CA1的通路直接参与嗅觉相关联的学习行为。 在CA1的背侧存在两种形态和分子marker不同的锥体细胞：

The lateral entorhinal cortex (LEC) provides multisensory information to the hippocampus, directly to the distal dendrites of CA1 pyramidal neurons. LEC neurons perform important functions for episodic memory processing, coding for contextually ...