2000年2月4日 · The SCN is a small, paired, wing-shaped structure in the hypothalamus, located at the base of the brain. The animation shows the isolated left SCN, optic nerve, and eye, while the right SCN is shown embedded within the hypothalamus in the brain.

2021年9月24日 · Here we identify a vascular pathway in mouse for communication of diffusible signals in a hypothalamic portal system connecting the SCN and a nearby circumventricular organ (CVO), namely the...

The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals. Individual SCN neurons in dispersed culture can generate independent circadian oscillations of clock gene expression and neuronal firing. However, SCN rhythmicity ...

2000年10月27日 · We analyzed gene expression in the hypothalamic circadian clock, the suprachiasmatic nucleus (SCN), of behaviorally “split” hamsters housed in constant light. The results show that the two oscillators underlying the split condition correspond to the left and right sides of the bilaterally paired SCN.

The left SCN represents the neurochemical identity of the ventrolateral portion of the nuclei, in neurons that express clock genes in response to light and are directly innervated by the RHT, the...

2020年9月30日 · Stimulation of the SCN region drives a variety of GABA and glutamate driven responses in downstream target neurons. a Schematic of typical ex vivo recording and stimulation configuration (left) and proportions of isolated neurons exhibiting various classes of response to electrical stimulation as a function of dorsal-ventral location (right; n.r...

The central circadian pacemaker of the suprachiasmatic nuclei (SCN) is a bilaterally symmetrical structure. Little is known about the physiological mechanisms underlying communication between the left and right SCN and yet the degree of synchronization between SCN neurons can have a critical impact …

2020年3月21日 · The SCN receives photic time cues via the retinohypothalamic tract (RHT) to reset the circadian phase to environmental light–dark (LD) cycles, and sends LD-entrained circadian signals to downstream brain areas and body tissues in order to coordinate the timing of overt rhythms (Reppert & Weaver, 2002).

2023年8月1日 · The supraclavicular lymph node (SCN) is a common metastatic site for malignancies of supra and infra-diaphragmatic origin and is easily accessible for small biopsy and fine needle aspiration (FNA). In this study, the utility of SCN biopsies was analyzed for diagnosis and ancillary studies.

Background: The supraclavicular lymph node (SCN) is a common metastatic site for malignancies of supra and infra-diaphragmatic origin and is easily accessible for small biopsy and fine needle aspiration (FNA). In this study, the utility of SCN biopsies was …