利奈唑胺 （INN：linezolid）为一种人工合成的噁唑烷酮类 抗生素 [1]，主要抑制细菌蛋白质合成，可用于治疗由需氧的葡萄球菌、链球菌、肠球菌等耐药 革兰阳性菌 引起的感染 [2][3]，亦可用于耐多药 结核杆菌 治疗 [4]。

利奈唑胺为细菌蛋白质合成抑制剂，作用于细菌50S 核糖体亚单位，并且最接近作用部位。 与其它药物不同，利奈唑胺不影响肽基转移酶活性，只是作用于翻译系统的起始阶段，抑制mRNA与核糖体连接，阻止70S 起始复合物 的形成，从而抑制了细菌蛋白质的合成。 利奈唑胺的作用部位和方式独特，因此在具有本质性或获得性耐药特征的阳性细菌中，都不易与其它抑制蛋白合成的抗菌药发生交叉耐药，在体外也不易诱导 细菌耐药性 的产生。 通常导致阳性细菌对作用于50S 核糖 …

Linezolid is an antibiotic used for the treatment of infections caused by Gram-positive bacteria that are resistant to other antibiotics. [9][10] Linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA). [9 ...

Linezolid is an antibiotic that is commonly used for the following infections caused by certain bacteria. Linezolid may not be appropriate for some of the infections listed above, depending on...

2024年6月4日 · What is linezolid? Linezolid is an antibiotic that fights bacteria in the body. Linezolid is also an MAO (monoamine oxidase) inhibitor. Linezolid is used to treat different types of bacterial infections, such as pneumonia, skin infections, and infections that are resistant to other antibiotics.

2024年3月1日 · Linezolid is a synthetic oxazolidinone antimicrobial drug indicated for gram-positive infections and approved for the treatment of bacterial pneumonia, skin and skin structure infections, and vancomycin-resistant enterococcal (VRE) infections, including infections complicated by bacteremia.

2025年3月1日 · Linezolid is used to treat certain bacterial infections in many different parts of the body, including certain types of skin infections or pneumonia. Linezolid belongs to the family of medicines called antibiotics. It works by killing bacteria or preventing their growth.

2024年9月25日 · 利奈唑胺（Linezolid），别名斯沃，是一种人工合成的恶唑烷酮类抗生素，于2000年获美国FDA批准，主要用于治疗革兰氏阳性球菌引起的感染。 利奈唑胺为细菌蛋白质合成抑制剂，作用于50S核糖体亚单位，且最接近作用部位。

Linezolid is a reversible and non-selective inhibitor of monoamine oxidase (MAO) enzymes and can therefore contribute to the development of serotonin syndrome when administered alongside serotonergic agents such as selective serotonin re-uptake inhibitors (SSRIs) or tricyclic antidepressants (TCAs). 9 Linezolid should not be used for the ...

Linezolid is used to treat certain infections caused by bacteria, including pneumonia and infections of the skin. Linezolid is in a class of antibacterials called oxazolidinones. It works by stopping the growth of bacteria. Antibiotics such as linezolid will not …