Lepirudin is an anticoagulant that functions as a direct thrombin inhibitor. Brand name: Refludan, Generic: Lepirudin rDNA for injection. Lepirudin is a recombinant hirudin [1] derived from yeast cells.

2005年6月13日 · Lepirudin is a protein-based direct thrombin inhibitor used as an anticoagulant in patients with heparin-induced thrombocytopenia.

来匹卢定是重组的水蛭素，是高度特异性的，凝血酶的直接抑制剂。 重组水蛭素能与凝血酶以1∶1比例形成高亲和力、不可逆的复合物,从而使凝血酶失去凝血活性。 即导致部分凝血活酶时间（APTT）增加。 来匹卢定由肾脏代谢和分泌。 静脉注射约45%可以从尿液中检测到，约35%由原形排出。 清除半衰期约为1.3小时。 严重肾功能不全是患者半衰期可能延长至2天。 最常见的不良反应是由于对凝血酶的直接抑制导致的出血：从穿刺部位及伤口出血、贫血或血红蛋白下降， …

Lepirudin is a heterodetic cyclic peptide composed of 65 amino acids joined in sequence and cyclised by three disulfide bridges between cysteine residues 6-14, 16-28 and 22-39. It is a highly specific inhibitor of thrombin and used as an anticoagulant in patients with heparin-induced thrombocytopenia.

Lepirudin, a recombinant hirudin, is a direct irreversible thrombin inhibitor by binding to both free and clot-bound thrombin. It is approved for treatment of heparin-induced thrombocytopenia (HIT), which is a serious antibody-mediated drug reaction mostly associated with the use of unfractionated heparin.

2022年8月11日 · REFLUDAN (lepirudin) is indicated for anticoagulation in patients with heparin-induced thrombocytopenia (HIT) and associated thromboembolic disease in order to prevent further thromboembolic complications. Initial Dosage. Anticoagulation in adult patients with HIT and associated thromboembolic disease:

Lepirudin (Refludan), Berlex Laboratories, USA and Canada; Pharmion, all other countries), a recombinant derivative of the naturally occurring leech anticoagulant hirudin, was the first direct thrombin inhibitor to be approved by the European Agency for the Evaluation of Medicinal Products and the U …

Detailed Lepirudin dosage information for adults. Includes dosages for Thrombocytopenia Drug Induced; plus renal, liver and dialysis adjustments.

Lepirudin is a recombinant hirudin derived from transfected yeast cells. The hirudins are direct thrombin inhibitors which render the thrombin molecule incapable of promoting fibrin formation and catalysing other haemostatic reactions.

Lepirudin is a recombinant protein with slight structural difference to the natural anticoagulant of the medicinal leech (hirudo medicinalis), hirudin. Lepirudin acts without cofactors and therefore belongs to the family of the direct thrombin inhibitors.