Tumour suppressor RNF43 is a stem-cell E3 ligase that induces ... - Nature
2012年8月15日 · a, Graph of the expression pattern of stem-cell genes (Lgr5, Olfm4, Ascl2 and Tnfrsf19) and two RING-type E3 ubiquitin ligases (Rnf43 and Znrf3).Every fraction is …
肿瘤干细胞标志物：LGR5 - 知乎 - 知乎专栏
2022年12月15日，Carina Biotech宣布已提交其治疗实体瘤的LGR5 CAR-T ... RNF43和ZNRF3是跨膜E3连接酶，通过泛素化卷曲受体负调控wnt信号。这些酶是Wnt靶标，从细胞表面去 …
Unlike LGR4, LGR5 potentiates Wnt–β-catenin signaling without
LGR4 and LGR5 encode two homologous receptors with critical, yet distinct, roles in organ development and adult stem cell survival. Both receptors are coexpressed in intestinal crypt …
LGR4 and LGR5 form distinct homodimers that only LGR4 ... - Nature
2023年7月4日 · LGR4 and LGR5 are two homologous receptors that potentiate Wnt/β-catenin signaling in response to R-spondin (RSPO) ligands. The RSPO and LGR4 complex binds to …
Structure and function of LGR5: An enigmatic G‐protein coupled …
2014年2月20日 · LGR5 is a Wnt target gene 28 and was discovered by researchers trying to find an interstitial stem cell marker. 29 It has been known for many decades that the intestinal …
肿瘤干细胞标志物：LGR5 - 健康界
2023年1月5日 · LGR5在各种癌症组织中均被证实上调，如基底细胞癌、肝细胞癌、结直肠肿瘤和巢肿瘤。 ... RNF43和ZNRF3是跨膜E3连接酶，通过泛素化卷曲受体负调控wnt信号。这些酶 …
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
Both E3 ligases were found to be specific to Lgr5 crypt stem cells (Koo et al. 2012) and enriched in colon cancer (Hao et al. 2012). Both proteins show, in their basic structure and sequence, …
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces
2012年8月30日 · LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. Here we find that the related RNF43 …
without RSPO, whereas LGR5 did not interact with either E3 ligase with or without RSPO.Domain-swapping experi - ments with LGR4 and LGR5 revealed that the seven-transmembrane …
Unveiling LGR5: Prostate cancer's hidden stem cell and
2024年12月1日 · In adult stem cells, Lgr5/R-Spondin/Rnf3 enhances Wnt signalling. Wnt targets genes for Rnf3 and ZnrF, which are the 2 transmembrane E3 ligases that get rid of Wnt …