肿瘤干细胞标志物：LGR5 - 知乎 - 知乎专栏
LGR5还能通过激活Wnt/β-catenin信号通路促进乳腺癌细胞的癌细胞迁移、肿瘤形成和上皮-间质转化。 另一方面，LGR5已被证明能负向调节Wnt/β-catenin信号。 LGR5缺失的小鼠展现了Wnt …
来看！为你翻译了这篇Cell综述，不再遗憾错过Wnt信号通路 - 知乎
2023年6月4日 · Lgr4 和 Lgr5 之间，存在强烈的遗传相互作用，以维持双突变小鼠隐窝中的 Wnt 信号强度。 最近的研究表明，Wnts 本身不足以促进 Lgr5+干细胞的自我更新，而是通过维持 …
Neonatal Wnt-dependent Lgr5 positive stem cells are essential for ...
2019年11月26日 · Lgr5 is a facultative component of the Wnt receptor complex, functioning to amplify canonical Wnt signaling on stem cell populations through interaction with its family of …
LGR5 interacts and cointernalizes with Wnt receptors to
LGR5, a seven-transmembrane domain receptor of the rhodopsin family, is a Wnt target gene and a bona fide marker of adult stem cells in the gastrointestinal tract and hair follicle bulge. …
LGR5 Interacts and Cointernalizes with Wnt Receptors To Modulate Wnt…
Leucine-rich repeat-containing, G protein-coupled receptor 5 (LGR5) is a target of Wnt signaling and a bona fide marker of adult stem cells of the intestinal crypts, stomach, and hair follicle …
《文献分享·第四期》通过标记基因Lgr5鉴定小肠和结肠干细胞
Lgr5基因（eucine-rich-repeat-containing G-protein-coupled receptor 5, 也称Gpr49)，是从肠道Wnt靶位的诸多基因中挑选出的，只在小肠绒毛的凹陷处（crypt）表达。 由于 Wnt信号 构成 …
Lgr5 homologues associate with Wnt receptors and mediate R ... - Nature
2011年7月4日 · Lgr5 homologues are facultative Wnt receptor components that mediate Wnt signal enhancement by soluble R-spondin proteins. These results will guide future studies …
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt ...
2013年1月27日 · The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as …
Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin
2009年3月1日 · The Wnt target gene Lgr5 has been recently identified as a novel stem cell marker of the intestinal epithelium and the hair follicle. In the intestine, Lgr5 is exclusively …
Lgr5 homologues associate with Wnt receptors and mediate R …
2011年7月4日 · Lgr5 homologues are facultative Wnt receptor components that mediate Wnt signal enhancement by soluble R-spondin proteins. These results will guide future studies …