2024年12月25日 · LGR6 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 6) is a Protein Coding gene. Diseases associated with LGR6 include Myxedema and Ankyloglossia With Or Without Tooth Anomalies. Among its related pathways are Signaling by WNT and ncRNAs involved in Wnt signaling in hepatocellular carcinoma.

Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene. [5] [6] Along with the other G-protein coupled receptors LGR4 and LGR5, LGR6 is a Wnt signaling pathway mediator. LGR6 also acts as an epithelial stem cell marker in squamous cell carcinoma in mice in vivo. [7]

2021年9月6日 · Thus, our study demonstrated that LGR6 activated a novel β-catenin/TCF7L2/LGR6-positive feedback loop in LGR6 high cervical cancer stem cells (CSCs), which provided a new therapeutic strategy...

LGR6是新近分离出来的糖蛋白激素受体家族的新成员,对分离出来的全长cDNA及其编码的蛋白质序列初步分析结果显示,该受体属于富含亮氨酸重复序列的G-蛋白偶联受体.

2022年5月2日 · LGR6 (leucine-rich repeat containing, G protein-coupled receptor 6) is a member of the rhodopsin-like seven transmembrane domain receptor superfamily with the highest homology to LGR4 and LGR5. LGR6 was found as one of the novel genes mutated in ...

Leucine‐rich repeat–coupled receptor 6 (LGR6) is a marker of the skin, nails, and other types of adult tissue stem cells and has been widely found to be related to the development and progression of a variety of cancer types.

2024年10月1日 · LGR6 knockout aggravated but cardiomyocyte-specific LGR6 overexpression ameliorated the cardiac dysfunction and remodeling in diabetic mice. Mechanistically, in vivo and in vitro experiments revealed that LGR6 deficiency aggravated ferroptosis and disrupted mitochondrial biogenesis by regulating STAT3-Pgc1a signaling, whereas LGR6 ...

2020年9月25日 · Leucine-rich-repeat-containing G protein-coupled receptor 6 (LGR6) has been identified as the stem cell marker in multiple normal tissues and malignancies. Previous studies implicated paradoxical functions of LGR6 as a tumor-suppressor gene or oncogene given to the specific context.

该基因编码 G 蛋白偶联 7 跨膜蛋白超家族中富含亮氨酸重复序列的亚组成员。 编码的蛋白质是一种糖蛋白激素受体，具有一个大的 N 末端细胞外结构域，该结构域包含富含亮氨酸的重复序列，对于形成配体结合的马蹄形相互作用基序很重要。 该基因的可变剪接导致多个转录变体。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily.

2025年2月8日 · LGR6 is a potential diagnostic and prognostic marker for esophageal squamous cell carcinoma. Epithelial stem cell marker LGR6 expression identifies a low-risk subgroup in human papillomavirus positive oropharyngeal squamous cell carcinoma.