2020年5月8日 · Lgr6 is a marker for distinct stem cells and is able to give rise to all lineages of the skin (HF, sebaceous gland and interfollicular epidermis) [21]. Sox9 is a transcription factor expressed in the sebaceous and sweat glands and the …

2010年3月12日 · Lgr6 is thus one of the earliest placode markers, resembling Sonic Hedgehog (24) and Sox9 (25). Lgr6 expression persisted during hair peg development (Fig. 1C and fig. S2C). The resulting hair breaks through the overlying epidermis postnatally.

2024年6月11日 · Lgr6的表达在肿瘤细胞中增加，反映了肿瘤从正常稳态向恶性发展过程中的功能转换。 Lgr5在毛囊下凸起区域高表达，反映了其已知的毛囊干细胞功能，且Lgr5在癌变的所有阶段均低表达。

2011年4月12日 · We report, for the first time, an in vitro culture method to isolate Lgr6-positive stem cells from HFs. HFSCs represent a unique tool for studying the cell characteristics of Lgr6-positive cells and should provide a novel easily accessible source for regenerative therapies.

2020年5月8日 · In order to understand the presence and potential contribution of stem cells (SCs) as tumour-initiating cells in canine cutaneous tumours, we selected three putative SC markers (Lgr5, Lgr6 and Sox9) and investigated their expression pattern, level of protein and mRNA expression, in 43 canine hair follicle (HF) and 18 canine cutaneous epidermal ...

Using a multimodal approach for a head-to-head comparison of injury-induced SOX9 lineages, we identified a dynamic SOX9 switch in repairing epithelia. Lineages that regenerated epithelia silenced SOX9 and healed without fibrosis (SOX9 on-off).

Here, we provide the first report describing the differentiation of human iPSCs into NS-like cells expressing the nail stem cell marker Lgr6, for future applications in drug screening and cell administration therapy. All animals used in this study were handled according to the Kansai Medical University ethical guidelines for animal experiments.

Objectives: To investigate the expression of potential stem cell markers, such as leucine-rich repeat-containing G protein-coupled receptor (Lgr) 5, Lgr6, leucine-rich repeats and immunoglobulin-like domain protein 1 (Lrig1) and cytokeratin 15 (CK15) in basal cell carcinomas and tumours of the skin appendages.

Hair follicle stem cells (HFSCs) arise within the early committed placode epithelium before the physical appearance of the bulge. These Sox9 + HFSCs localize to the suprabasal layer and are the earliest long-term label-retaining stem cells (red). Sox9 appears to …

Lgr6+ stem cells from tumors generated progeny that expressed lineage plasticity markers Sox2, Pitx1, Foxa1, and Cd44, as well as genes associated with quiescence and tumor suppression. This cell state was strongly anticorrelated with an alternative state expressing markers of cell proliferation and DNA damage responses.