2021年9月6日 · Here, immunohistochemistry and western blotting showed that LGR6 was significantly upregulated in cervical cancer, compared with the normal cervix. By analyzing The Cancer Genome Atlas database,...

Our results showed that LGR6 acts as an oncogene in TNBC and promotes tumor progression by the Wnt/β-catenin pathway, indicating that LGR6 may serve as a potential therapeutic target in TNBC. We measured the expression levels of LGR6 in both breast cancer cell lines and tissues.

2023年8月9日 · The lncRNA LITTIP is identified to negatively regulate cementogenesis, which activates Wnt/β-catenin signaling via high expression of LGR6 promoted by HnRNPK.

2019年10月29日 · These results reveal that LGR6 is highly expressed in osteoblastic progenitors, and promotes osteogenesis by enhancing β-catenin stability to strengthen the Wnt signaling pathway. This study provides an important reference into the exact mechanisms of …

2020年6月24日 · Functional assays both in vitro and in vivo showed that LGR6 promotes tumor proliferation and metastasis. LGR6 also increased the ability of tumor spheroid formation. Underlying mechanism exploration further revealed that the oncogenic role of LGR6 might be associated with the Wnt/β-catenin pathway.

The leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) is considered to be a stem cell marker in many normal tissues and promotes tissue development, regeneration, and repair. LGR6 is also related to the initiation and progression of some malignant tumors.

Previously, we identified the association of leucine-rich repeat-containing G protein-coupled receptor 6 (LGR6) with oncogenic Wnt signaling, and its downregulation upon β-catenin knockdown in non-small cell lung cancer (NSCLC) cells carrying CTNNB1 mutations.

LGR6 promotes tumor growth and metastasis both in vitro and in vivo, which might be associated with the Wnt/b-catenin pathway. Therefore, our findings reveal that LGR6 acts as an oncogene in

This is the first study to confirm that the existence of a novel β-catenin/TCF7L2/LGR6-positive feedback loop in cervical cancer, and LGR6 induces its own expression via the β-catenin/TCF7L2/LGR6 loop to further activate the Wnt signaling.

2020年9月25日 · Our results showed that LGR6 acts as an oncogene in TNBC and promotes tumor progression by the Wnt/β-catenin pathway, indicating that LGR6 may serve as a potential therapeutic target in TNBC. We measured the expression levels of LGR6 in both breast cancer cell lines and tissues.