The leukocyte immunoglobulin-like receptors (LILR) are a family of receptors possessing extracellular immunoglobulin domains. [1] They are also known as CD85, ILTs and LIR, and can exert immunomodulatory effects on a wide range of immune cells. [2] The human genes encoding these receptors are found in a gene cluster at chromosomal region 19q13.4.

Human leukocyte immunoglobulin (Ig)-like receptors (LILR) are a family of 11 innate immunomodulatory receptors, primarily expressed on lymphoid and myeloid cells. LILRs are either activating (LILRA) or inhibitory (LILRB) depending on …

2015年6月4日 · Human leukocyte immunoglobulin-like receptors (LILR) are a family of 11 functional genes encoding five activating (LILRA1, 2, 4–6), five inhibitory (LILRB1–5) and one soluble (LILRA3)...

2020年5月13日 · The leukocyte immunoglobulin-like receptor (LILR) family contain activating and inhibitory members that can up- or down-regulate immune cell activity. New ligands and functions for LILR continue to emerge.

We focus on the current knowledge of LILR expression on neutrophils, the known functions of LILR on neutrophils, and how these receptors may contribute to shaping neutrophil responses during infection.

The leukocyte immunoglobulin-like receptors (LILRs), also known as Ig-like transcripts (ILTs), are a family of immunoregulatory receptors expressed by a range of hematopoietic cell types, including monocytes, macrophages, dendritic cells, granulocytes, natural killer (NK) cells, T cells, and B cells. 1 The LILR family consists of both ...

2021年9月14日 · Here, we review the genetic organisation, structure and ligands of LILRs as well as their role in regulating the immune response and inflammation. We also discuss the LILR-based strategies that pathogens use to evade immune responses.

2015年6月5日 · LILRs have diverse functions, including the regulation of inflammation, immune tolerance, cell differentiation and nervous system plasticity. This review focuses on the genetic and functional diversity of the LILR family.

In this review, we will summarize recent research on the function and potential roles of LILRs in the context of different disease conditions and cancer development and how LILRBs can be targeted to convert the immunosuppressive function of …

2018年1月1日 · The leukocyte immunoglobulin (Ig)-like receptor (LILR) multigene family consists of two pseudogenes (LILRP1 and LILRP2) and 11 functional genes that encode five activating (LILRA1, LILRA2, LILRA4, LILRA5, and LILRA6), five inhibitory (LILRB1, LILRB2, LILRB3, LILRB4, and LILRB5), and one soluble (LILRA3) form.