Linkage analysis is one of two complementary strate-gies currently used for gene-mapping, the other being association analysis. Broadly speaking, linkage is designed to localize a region of the genome where a locus or loci that regulate the expression of a trait may be harbored.

2021年10月25日 · Linkage analysis relies on the fact that disease-causing mutations are inherited jointly (linked) with genetic markers located in their immediate vicinity. In order for a gene and a genetic marker to be linked, they must be syntenic, meaning they …

Here, we review the principles of linkage analysis and provide practical guidelines for carrying out linkage studies using WGS data. Linkage analysis was the predominant statistical genetic mapping approach used in the latter half of the twentieth century.

Linkage analysis is the method of associating the functionality of genes to their chromosomal locations by looking for evidence of cosegregation between genes and similarity in phenotypes between individuals who share alleles at those marker loci.

2015年3月31日 · Linkage analysis was the predominant statistical genetic mapping approach used in the latter half of the twentieth century. More recently, the focus shifted to association studies of...

2007年9月1日 · Linkage analysis is the method of associating the functionality of genes to their chromosomal locations by looking for evidence of cosegregation between genes and similarity in phenotypes between individuals who share alleles at those marker loci.

Linkage analysis was developed to detect excess co-segregation of the putative alleles underlying a phenotype with the alleles at a marker locus in family data. Many different variations of this analysis and corresponding study design have been ...