2020年2月1日 · The binary-lipid system of soybean phosphatidylcholine (SPC) and glycerol dioleate (GDO) can hydrate to gels on contacting with aqueous mediums, which has emerged as a versatile and promising delivery matrix for extended drug release applications.

2022年4月1日 · Initial burst release (IBR) was evaluated for the lipid liquid crystals (LLCs) containing glycerol monooleate (GMO), glycerol dioleate (GDO), and glycerol trioleate (GTO), along with different percentages of phosphatidylcholine (PC) as the oil phase, and N-methyl-2-pyrrolidone (NMP) as the solvent.

2014年4月29日 · In the second part of the study we show how the structure of the particles evolves during exposure to a triacylglycerol lipase (TGL) under physiological-like temperature and pH. TGL catalyzes the lipolytic degradation of acylglycerides, such as GDO, to monoglycerides, glycerol, and free fatty acids.

2022年1月5日 · Camurus' FluidCrystal® injection depot is a lipid liquid crystal (LLC) phase formation-based method, comprising of glycerol dioleate (GDO) and soy phosphatidylcholine (SPC), together with minute quantities of N-methyl-2-pyrrolidone solvent (NMP).

2017年7月24日 · Experimentally, the relationship between phase structures of lipid liquid crystal system—soy phosphatidyl choline (SPC) and glycerol dioleate (GDO) in water were characterized by polarized light microscopy and small angle X-ray diffraction.

The binary-lipid system of soybean phosphatidylcholine (SPC) and glycerol dioleate (GDO) can hydrate to gels on contacting with aqueous mediums, which has emerged as a versatile and promising delivery matrix for extended drug release applications.

Monitoring of nanoparticle-based therapy in vivo and controlled drug release are urgently needed for the precise treatment of disease. We have synthesized a multifunctional Gd-DTPA-ONB (GDO) lipid by introducing the Gd-DTPA contrast agent moiety into an o-nitro-benzyl ester lipid.

The purpose of this project was to develop and test lipase-based in vitro release (IVR) assays for model and active pharmaceutical ingredients (API) entrapped in lipid formulations based on mixtures of phosphatidylcholine (PC) and glycerol dioleate (GDO).

The lipids (35/65 wt%/wt% SPC/GDO) were mixed with small fractions of ethanol and propylene glycol (PG) (85/10/5 wt%/wt%/wt% lipid / EtOH /PG) to reduce the viscosity of the formulation and facilitate spreading during the spin-coating procedure.

2019年11月1日 · Here we present a new approach of combining tracing and dual-trigger controlled-release capabilities in a single lipid molecule (Gd-DTPA-ONB lipid, abbreviated as GDO lipid) to create a drug carrier for precision medicine.