2024年9月4日 · ACE inhibitors induce angioedema in 0.1 to 0.7 percent of recipients, with data suggesting a persistent and relatively constant risk over time . The incidence of ACE inhibitor-induced angioedema is up to five times greater in people of African descent .

2015年2月8日 · ACE-inhibitor induced angioedema (ACEI-AAG) accounts for about a third of angioedema cases presenting to the emergency department. ACE inhibitors are increasingly popular, with the new JNC 8 guidelines up-grading them to a first-line drug for hypertension.

Inhibition of the angiotensin‐converting enzyme and subsequent blockade of bradykinin degradation is thought to be a likely explanation for ACEI‐induced angioedema. Studies have shown that blacks, women, and smokers are at an increased risk for ACEI‐induced angioedema.

2023年9月25日 · Angioedema can come on suddenly, even after taking an ACE inhibitor like lisinopril safely for years. Swelling of the lips, mouth, tongue or throat are signals of this reaction and can quickly become life threatening.

2002年9月15日 · Angioedema associated with the use of ACE inhibitors usually presents as episodic attacks of swelling of the face, tongue, and airways, but it may also involve visceral tissues.

2022年8月5日 · ACE inhibitor-induced angioedema can happen to anyone who takes ACE inhibitors for their blood pressure. And the condition can be life-threatening. Learn if you’re at risk and the signs to look out for.

What is ACE inhibitor-induced angioedema? ACE inhibitor -induced angioedema is a rare but potentially fatal adverse effect of the class of medications that inhibit angiotensin converting enzyme (ACEi). It typically presents in the first weeks after starting the ACEi as swelling of the face, lips, or tongue in the absence of itch or urticaria.

Angiotensin-converting enzyme inhibitors (ACEI) are a common cause of drug-induced angioedema in the United States. Most epidemiologic ACEI angioedema data are from large multi-center clinical trials.

ACEI-induced angioedema is a rare entity but can result in life-threatening emergencies. It mainly occurs in patients starting on ACEI as an antihypertensive. We present a case of lisinopril-induced angioedema in an African American patient managed in the emergency department.

A 38-year-old male on lisinopril developed throat angioedema in March 2023 necessitating ED visit and two-day ICU stay. Responsive to epinephrine within minutes. No tracheostomy required.