2024年12月25日 · LITAF (Lipopolysaccharide Induced TNF Factor) is a Protein Coding gene. Diseases associated with LITAF include Charcot-Marie-Tooth Disease, Demyelinating, Type 1C and Charcot-Marie-Tooth Disease Type 1C .

2024年1月5日 · The strongest candidate (LITAF) was validated via gene overexpression, KO, and mutation approaches in assays of cell survival. Confocal microscopy and biochemical assays (Western blot, immunoprecipitation) were used to determine the mechanism of action. We generated a LITAF-KO mouse using CRISPR to validate the role of LITAF in primary ...

LITAF, a BCL6 target gene, regulates autophagy in mature B-cell lymphomas. The findings indicate a function of SIMPLE as a regulator of endosomal trafficking and provide evidence linking dysregulated endosomal trafficking to CMT pathogenesis.

2013年7月10日 · The LITAF gene encodes a transcription factor, first identified as a regulator of TNF-alpha (TNF; 191160) gene expression (Takashiba et al., 1995). The LITAF gene product is an early endosomal membrane protein enriched in the peripheral nerves and Schwann cells (summary by Lee et al., 2011).

A recent study for the first time has demonstrated that LITAF, a novel target of BCL6, regulates autophagy in mature B-cell lymphomas . This study provided evidences for the transcriptional repression of LITAF by BCL6 in B cells. Here, we found that there may be a reciprocal feedback loop between LITAF and BCL6.

LITAF (LPS-induced TNF-activating factor) is an endosome-associated integral membrane protein important for multivesicular body sorting. Several mutations in LITAF cause autosomal-dominant Charcot Marie Tooth disease type 1C.

2024年1月5日 · We identify the endolysosomal protein LITAF as a mediator of cellular resistance to PFT-induced cell death that is active against both bacterial toxins and the endogenous pore, gasdermin D, a terminal effector of pyroptosis.

Mechanistically, LITAF directly binds to the N-terminal of ASK1, thus disrupting the dimerization of ASK1 and blocking ASK1 activation, ultimately inhibiting ASK1-JNK/p38 signaling over-activation and protecting against cardiac hypertrophy.

Gene expression and immunohistochemical studies revealed that LITAF and BCL6 show opposite expression in tonsil B-cell subpopulations and B-cell lymphomas, suggesting that BCL6 may regulate LITAF expression.

2021年5月15日 · LITAF, also named as p53-inducible gene 7 (PIG7), was initially identified and characterized in the human macrophage cell line THP-1 after stimulation with LPS (Takashiba et al., 1995, Myokai et al., 1999).