Livedoid vasculopathy is a clinical diagnosis, supported by skin biopsy of a red papule or the edge of a new ulcer. Histopathology reveals hyalinisation, thickened blood vessel walls, fibrin deposition, vascular occlusion by thrombosis and minimal inflammation.

2024年3月1日 · Livedoid vasculopathy is characterized by punched-out ulcers in the perimalleolar area surrounded by lacy, reticular, reddish to violaceous streaks, also known as livedo reticularis. These ulcers heal, forming porcelain white scars surrounded by telangiectasias and represent the vestiges of cutaneous infarction due to disturbed capillary ...

Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin ...

Livedoid vasculopathy (LV) is a rare, chronic, and occlusive disease of the veins supplying the upper parts of the skin. The pathogenesis of the disease is not precisely understood, and its attacks are often unpredictable but tend to worsen during the …

2025年1月22日 · This review discusses the pathophysiology, risk factors, clinical aspects, differential diagnoses, histopathology, presents a therapeutic update of livedoid vasculopathy, calciphylaxis, and Martorell’s ulcer.

Long-term use of 10 mg daily rivaroxaban demonstrated positive responses in the Chinese LV population. Individualized dose titration of rivaroxaban, including discontinuation and retreatment based on the severity and preferences may provide a reliable and well-tolerated option to induce remission and maintenance for patients with LV.

Livedoid vasculopathy (LV) is an uncommon thrombotic dermal vasculopathy that is characterized by excruciating, recurrent ulcers on the lower limbs. [4] . Livedo racemosa, along with painful ulceration in the distal regions of the lower extremities, is the characteristic clinical appearance.

2023年9月29日 · Livedoid vasculopathy is usually associated with phenomena that cause hypercoagulability and thrombus formation, including : chronic venous hypertension of the limbs and varicose veins, autoimmune connective tissue diseases (systemic lupus erythematosus, rheumatoid arthritis, scleroderma, mixed connective tissue disease), thrombophilia states ...

2013年2月26日 · Livedoid vasculopathy is a rare, chronic, recurrent disease of the cutaneous microcirculation. Its typical clinical manifestation is a triad which consists of livedo racemosa of the skin, episodic painful ulcerations of the distal aspects of the legs and a healing process leaving small porcelain-white scars called atrophie blanche.

Purpose: Livedoid vasculopathy (LV) is a chronic microvascular thrombosis disorder with an unclear pathogenesis, potentially involving hypercoagulability and inflammation. This systematic review aims to evaluate the efficacy and safety of Janus kinase (JAK) inhibitors and biologics in the treatment of LV.