2016年3月14日 · Natural killer T (NKT) cells are innate-like lymphocytes that generally recognize lipid antigens and are enriched in microvascular compartments of the liver. NKT cells can be activated...

2020年11月10日 · Here, we report the profiling of NKT (NK1.1 + CD3e +) cells in livers from wild type (WT), Jα18-deficient and CD1d-deficient mice by single-cell RNA sequencing. Unbiased transcriptional...

2022年10月26日 · The relationship between NKT cells and other cells in liver disease. In the liver, NKT cells have close connections with other cells including hepatocytes (normal liver cells), dendritic cells, macrophages (Kupffer cells), T cells, and B cells, and are able to regulate their functions during innate and acquired immune reactions.

Hepatic lymphocytes are enriched in NK and NKT cells that play important roles in antiviral and antitumor defenses and in the pathogenesis of chronic liver disease. In this review, we discuss the differential distribution of NK and NKT cells in mouse, rat, …

NK/NKT CELLS IN LIVER INJURY. NK and NKT cells in the liver play a key role in innate defenses against viral infection and tumor transformation. Recent evidence suggests that activation of NK or NKT cells also contributes to the development and progression of liver injury in a variety of rodent models [38, 109].

2021年11月19日 · Natural killer T (NKT) cells, a T cell subset expressing surface markers of both natural killer cells and T lymphocytes and involved in antitumor immunity, are another...

2022年10月26日 · A better understanding of hepatic iNKT cells is necessary for finding new methods of treating liver disease including autoimmune liver diseases, alcoholic liver diseases (ALDs), non-alcoholic fatty liver diseases (NAFLDs), and liver tumors.

2003年7月1日 · The liver is a rich provenance of an unconventional group of T cells called natural killer T (NKT) cells that coexpress NKR-P1, a type II membrane glycoprotein of the C-type lectin superfamily (NK1.1). Accumulating evidence suggests that NKT cells comprise a far more heterogeneous population than originally thought.

2024年7月1日 · Selective immunomodulation of iNKT cells with the specific activator α-GalCer resulted in proinflammatory cytokine production and prevented infections following stroke. These observations offer further insight into the complex role of NKT cells in chronic liver immunopathology.

We hypothesized that NKT cells accumulate and promote fibrosis progression in NASH. We aimed to determine if livers become enriched with NKT cells during NASH-related fibrosis; identify responsible mechanisms; and assess if NKT cells stimulate fibrogenesis.