2024年9月1日 · This study provides compelling evidence substantiating the potential therapeutic use of NTCP inhibitors for managing liver fibrosis. These findings demonstrated that BAs …

Sodium/bile acid cotransporter also known as the Na +-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the …

Sodium taurocholate co-transporting polypeptide (NTCP), a transmembrane protein highly expressed in human hepatocytes and a mediator of bile acid transport, has been identified as …

Objective: Sodium + / taurocholate cotransporting polypeptide (NTCP) is a membrane transporter affecting the enterohepatic circulation of bile acids (BAs). We aimed to evaluate NTCP's roles …

2022年5月11日 · Human Na + –taurocholate co-transporting polypeptide (NTCP) is the main bile salt uptake system in liver. NTCP is also the cellular entry receptor of...

2022年6月20日 · The sodium taurocholate (TC) co-transporting polypeptide NTCP (SLC10A1) is a secondary active membrane transport protein that mediates the uptake of bile salts from the …

6 天之前 · It has been established that Shp is the upstream regulatory gene for both Ntcp and Cyp7a1 and FXR inhibits Ntcp and Cyp7a1 production via increasing Shp (Zhang et al., 2020). …

相关研究结果于2022年5月11日在线发表在Nature期刊上，论文标题为“Structural basis of sodium-dependent bile salt uptake into the liver”。 这些作者能够描述两种基本的NTCP构象：第一种构 …

2021年8月1日 · Pharmacological NTCP inhibition is hepatoprotective in cholestasis. HBV/HDV entry requires NTCP and can be inhibited by a pre-S1 mimicking peptide. Inhibition of NTCP …

In this review, we will examine the regulatory mechanisms governing HBV pre-S1 binding to liver membrane NTCP, the role of NTCP in HBV internalization, and the transcriptional and …