本实验采用免疫组织化学方法联合检测肝细胞癌组织及正常肝组织中PTEN、Akt及pAkt蛋白的表达, 分析其与肝细胞癌临床病理特征及预后的关系, 初步探讨他们在肝细胞癌中表达的意义及预后 …

2024年1月2日 · The modulation of the balance between TGF-β signaling to Smad2/3 vs. pAkt (by TGF-β or EGF) has potential implications for hepatic diseases and malignancies.

随着渥曼青霉素浓度的增加及作用时间的延长, HepG2细胞凋亡率逐渐升高 (8.46%±1.17%至28.03%±2.67%) (P <0.05). Western blot结果显示渥曼青霉素可下调pAkt和Skp2蛋白的表达, 上 …

HCC without viral background displayed a significant increase for the eIF subunits p-2α, 3C, 3I, 4E and 4G. We noticed engraved differences in the expression pattern between chronic …

目的:通过特异性阻断PI3K和mTOR,观察HepG2和Hep3B细胞株PI3K/Akt/mTOR信号通路活性及生物学行为的改变,探讨相关的分子机制.方法:在培养的HepG2,Hep3B人肝癌细胞株和人正常肝 …

2022年2月17日 · Tissue pAkt relative to total Akt level (pAkt/tAkt) was measured to provide an index of insulin signal transduction activation and a dose-dependent increase for pAkt in liver …

P27kip1 was expressed in 34.6% samples of HCC, and significantly lower than that in normal liver tissue (P ＜0.05). pAkt expression level was correlated with tumor size, invasion (or lymph …

Immunohistochemistry and immunofluorescence (IF) were conducted on human healthy and primary biliary cholangitis (PBC) liver samples as well as on liver samples obtained from …

Conclusions: MiR-125b loss activated the HIF1α/pAKT loop, contributing to HCC resistance to TACE and the key nodes in this axis hold the potential in assisting patients with HCC to …

Comparison of western blotting against pAkt and Akt in major organs among the experimental groups: heart (a, b), liver (c, d), and kidney (e, f). Data are presented as means±s.d.. The data …