LKB1 encodes a serine–threonine kinase that directly phosphorylates and activates AMPK, a central metabolic sensor. AMPK regulates lipid, cholesterol and glucose metabolism in specialized...

In the past decade, studies of the human tumor suppressor LKB1 have uncovered a novel signaling pathway that links cell metabolism to growth control and cell polarity. LKB1 encodes a serine/threonine kinase that directly phosphorylates and activates AMPK, a …

2011年8月9日 · 研究 显示LKB1通过磷酸化磷酸腺苷激活的蛋白激酶(AMP-activated protein kinase, AMPK)，从而激活AMPK，实现对mTOR活性的负向调控。本文就LKB1-AMPK-mTOR信号通路及其在肿瘤中的研究进展进行简要的综述。

LKB1也称为STK11（serine/threonine kinase 11），通过激活AMPK抑制细胞生长和增殖，是一种抑癌因子。 其失活与多种肿瘤相关，特别是肺癌。 虽然叫肝激酶，但其实LKB1在人体各组织中普遍表达，在胰腺、肝脏和骨骼肌中的表达较高。 除AMPK外，LKB1还磷酸化12种AMPK样激酶（ [2]: Br J Cancer. 2015），参与调控细胞的生长、代谢、自噬、增殖、迁移、粘附、极性、应激等生理过程。 在DNA损伤反应中，激酶 ATM 被DNA双链断裂激活，通过LKB1激活AMPK和p53 …

LKB1 encodes a serine-threonine kinase that directly phosphorylates and activates AMPK, a central metabolic sensor. AMPK regulates lipid, cholesterol and glucose metabolism in specialized metabolic tissues, such as liver, muscle and adipose tissue. This function has made AMPK a key therapeutic target in patients with diabetes.

2012年7月17日 · In this study, the authors utilized the A549 lung cancer cell line, which exhibits homozygous inactivating mutations of endogenous LKB1, as a model to study LKB1-AMPK-dependent survival under...

2011年4月6日 · Studies from LKB1 and AMPK knockout mice, and the discovery of human disease-causing mutations in AMPK, have pointed to an important role for these signaling kinases in cardiac protection. The LKB1 cardiac-myocyte specific knockout mouse develops a cardiac hypertrophic phenotype by 12 weeks of age, and eventually succumbs to cardiac failure by ...

2013年4月15日 · AMPK is activated >100-fold on conversion from a dephosphorylated form (AMPK) to a form phosphorylated at Thr172 (AMPK-P) catalyzed by at least two upstream kinases: LKB1, which appears to be constitutively active, and CaMKKβ, which is only active when intracellular Ca 2+ increases.

LKB1 positively regulates the AMP-activated protein kinase (AMPK) and at least 12 additional AMPK-related downstream kinases, involved in the control of cell growth and metabolism and in the regulation of cellular response to energy stress and establishment of cell polarity .

2007年1月21日 · We present evidence that the cyclin-dependent kinase inhibitor p27 Kip1, is phosphorylated at Thr 198 downstream of the Peutz-Jeghers syndrome protein–AMP-activated protein kinase (LKB1–AMPK)...