Leptomeningeal disease (also known as LMD, leptomeningeal metastases, or LM) is cancer in your cerebrospinal fluid and in your leptomeninges, the membranes that surround your brain and spinal cord. It happens when an advanced cancer spreads from part of your body to your cerebrospinal fluid and leptomeninges.

2017年4月3日 · The Neuro-Oncology department at MD Anderson is expanding its LMD program dedicated to better understanding and treating the disease. Barbara O’Brien, M.D., assistant professor of neuro-oncology, recently spoke with us about leptomeningeal disease and our effort to help patients with this condition.

Leptomeningeal disease (LMD) is a late-stage complication of systemic cancers caused by multifocal metastases to the leptomeninges, which consist of the pia mater, arachnoid, and subarachnoid space.

Leptomeningeal disease (LMD) is a devastating complication caused by seeding malignant cells to the cerebrospinal fluid (CSF) and the leptomeningeal membrane. LMD is diagnosed in 5–15% of patients with systemic malignancy. Management of LMD is challenging due to the biological and metabolic tumor microenvironment of LMD being largely unknown.

What Is Leptomeningeal Disease (LMD)? Cancer cells can travel from one part of the body to another. LMD happens when cancer cells invade the fluid and protective membranes (called meninges) that surround the brain and spinal cord. Call 412-647-2811. Contact a UPMC Hillman Cancer Center near you. Fill out our online contact form. What causes LMD?

2024年6月18日 · Leptomeningeal disease (LMD) is a devastating complication of metastatic breast cancer (MBC). It is critical to better understand the risk factors, natural history, and treatment outcomes, including patients in a modern cohort.

2022年9月7日 · In a retrospective analysis being presented at ESMO, Glitza Oliva and her team examine whether newer therapies have improved survival for melanoma patients with LMD over the last few years. The findings show a small improvement, with 172 patients having a median overall survival of 4.9 months.

Leptomeningeal metastasis—also called leptomeningeal carcinomatosis, leptomeningeal disease, or simply “LMD”—is the spread of cancer to a particular part of the brain called the leptomeninges. It is different from brain metastases occurring inside the “meat” of your brain, because LMD grows in the lining of the brain, the leptomeninges.

2023年12月1日 · That’s when I was diagnosed with leptomeningeal disease (LMD). This occurs when cancer cells from primary tumors enter the leptomeninges, the outer lining of the brain and spinal cord. My wife and I had never heard of LMD, so we did some research.

2025年4月1日 · Leptomeningeal disease (LMD) is a devastating complication of metastatic cancer, characterized by the spread of malignant cells to the cerebrospinal fluid (CSF) and the leptomeninges. While historically associated with poor prognosis, advancements in diagnostics and therapeutic strategies are improving patient outcomes.