2021年11月23日 · Juvenile myelomonocytic leukemia (JMML) is a rare and frequently fatal myeloproliferative neoplasm of early childhood with an estimated incidence of 1.2 cases per million and a median age at disease onset of ~ 2 years. 1 Patients typically present with fever, splenomegaly, thrombocytopenia, and a high circulating white blood cell (WBC) count wit...

2021年7月13日 · Juvenile myelomonocytic leukemia (JMML) is a rare pediatric leukemia characterized by mutations in five canonical RAS pathway genes. The diagnosis is made by typical clinical and hematological findings associated with a compatible mutation.

2015年2月12日 · Juvenile myelomonocytic leukemia (JMML) is a unique, aggressive hematopoietic disorder of infancy/early childhood caused by excessive proliferation of cells of monocytic and granulocytic lineages. Approximately 90% of patients carry either somatic or germline mutations of PTPN-11, K-RAS, N-RAS, CBL, or NF1 in their leukemic cells.

2021年11月23日 · Juvenile myelomonocytic leukemia is an overlapping myeloproliferative and myelodysplastic disorder of early childhood . It is associated with a spectrum of diverse outcomes ranging from spontaneous resolution in rare patients to transformation to acute myeloid leukemia in others that is generally fatal.

La leucemia mielomonocítica juvenil (LMMJ) es un tipo de cáncer poco frecuente en la sangre y la médula ósea que se presenta en bebés y niños pequeños. Obtenga más información sobre el diagnóstico y tratamiento de la LMMJ

2023年11月1日 · Les leucémies myélo-monocytaires juvéniles (LMMJ) et les syndromes myélodysplasiques (SMD) de l’enfant sont des pathologies rares, fortement associées à la présence d’un syndrome de prédisposition sous-jacent.

Juvenile myelomonocytic leukemia (JMML) is a rare pediatric leukemia characterized by mutations in five canonical RAS pathway genes. The diagnosis is made by typical clinical and hematological findings associated with a compatible mutation.

2021年2月15日 · Juvenile myelomonocytic leukemia (JMML) is a rare pediatric myelodysplastic/myeloproliferative neoplasm overlap disease. JMML is associated with mutations in the RAS pathway genes resulting in the myeloid progenitors being sensitive to granulocyte monocyte colony-stimulating factor (GM-CSF).

2024年12月13日 · Información sobre el tratamiento de la leucemia mielomonocítica juvenil (LMMJ o JMML): trasplante de células madre y cuidados médicos de apoyo. Resumen para profesionales de la salud.

A leucemia mielomonocítica juvenil (LMMJ) é um câncer de sangue e medula óssea. A LMMJ ocorre com mais frequência em crianças menores de 4 anos. Cerca de 10% de todos os casos se desenvolvem em bebês com menos de 3 meses. A cada ano, 1 a 2 crianças a cada 1 milhão são diagnosticadas com LMMJ nos Estados Unidos. São 25-50 novos casos ...