2017年8月31日 · Lamin B receptor (LBR) is an integral protein of the inner nuclear membrane, containing a hydrophilic N-terminal end protruding into the nucleoplasm, eight hydrophobic segments that span the membrane and a short, nucleoplasmic C-terminal tail. Two seemingly unrelated functions have been attributed to LBR.

2023年2月19日 · Lamin B Receptor (LBR) is an inner nuclear membrane protein that assembles the nuclear envelope post mitosis. Here we show that LBR depletion induces mitotic defects accompanied by recurrent chromosomal losses. In addition, LBR knockdown results in nuclear aberrations such as nuclear blebs and micro …

摘要：核纤层蛋白B1 (Lamin B1)是核纤层蛋白家族重要成员之一，其主要功能在于维持细胞核骨架完整性，并通过影响染色体分布、基因表达及DNA损伤修复等参与细胞的增殖和衰老。 其表达异常与多种疾病有关，如神经系统疾病 (神经管畸形，ADLD)及肿瘤 (胰腺癌)等，是潜在的药物靶点和肿瘤标志物。 对Lamin B1功能的深入研究，将有助于对相关神经系统疾病和肿瘤发生发展的分子机制的了解并为治疗靶点研究提供新方向。 Corresponding author: Xiaowei Xing. Tel: +86 …

2024年6月1日 · Recent findings show that LMNB1 protein dysfunction interferes with the cellular senescence process, which is highly associated with tumor progression. LMNB1 expression levels vary in different...

One of these proteins is the lamin B receptor (LBR) that binds lamin B1 and tethers heterochromatin to the INM in embryonic and undifferentiated cells. It is replaced by lamin A/C with specific lamin A/C binding proteins at the beginning of …

Lamin B receptor (LBR) is an integral membrane protein of the interphase nuclear envelope (NE). The N-terminal end resides in the nucleoplasm, binding to lamin B and heterochromatin, with the interactions disrupted during mitosis.

2022年2月8日 · Another spectrum of pathologies connected to lamin B alterations involve mutations in the lamin B receptor (LBR). The LBR is an inner nuclear membrane protein that binds lamin B proteins (both lamin B1 and B2). Two different functions have been attributed to …

In this study, we analysed the functional effects of dysregulated nuclear lamin B1 (LMNB1) and its nuclear receptor (LBR). According to their cellular localisation and function, we revealed that...

2013年12月15日 · BACKGROUND: Lamin B (LMNB) and lamin B receptor (LBR) are key components of the nuclear envelope, with roles in chromosomal stability, DNA repair, and cell differentiation. Lamins provide structural support to the nuclear envelope, while LBR is believed to anchor lamin B to the envelope.

In addition to H3K27me3 and H3K9me2/3, A-type lamins and the inner nuclear membrane (INM) proteins lamina-associated polypeptide β (LAP2β) and Lamin B receptor (LBR) have been implicated in organizing LADs (19, 20, 21, 22). The nuclear lamina is a proteinaceous network of type V intermediate filaments comprising A and B type lamins.