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2019年5月17日 · Collectively, these findings show that mitochondrial targeting of LND is a promising therapeutic approach for investigating the role of autophagy in mitigating lung cancer development and brain...

2025年1月1日 · Diclofenac (DC) and lonidamine (LND), highly selective small molecular inhibitors targeting GLUT-1 and hexokinase 2 (HK-2), respectively, have been extensively investigated for their potential as glycolytic inhibitors to impede proliferation and …

The Global Mechanism and the secretariat of the UNCCD established the Land Degradation Neutrality Target Setting Programme (LDN TSP) to assist countries to achieve LDN by 2030. The programme takes countries through a structured process to help leverage, assess, measure and achieve their LDN commitments.

2017年12月7日 · Lonidamine（LND）可以作用于线粒体并抑制癌细胞中的能量代谢，因此已与化疗药物一起用于协同增强治疗效果。 然而，由于其在细胞质中的溶解性差和扩散缓慢，阻碍了它的使用。

This study reports the design and synthesis of a lonidamine (LND)-derived self-assembling peptide (LND-K) that dually targets integrin receptors and mitochondria of cancer cells. Under the precision guidance of a mitochondria-targeting sequence, LND-K-containing nanofibers target mitochondria and ablate mitochondrial functions.

2023年8月7日 · Mito-LND is a novel small-molecule inhibitor that can selectively inhibit the energy metabolism of tumor cells. However, the therapeutic effect of Mito-LND on GBM remains unclear. The present study evaluated the inhibitory effect of Mito-LND on the growth of GBM cells and elucidated its potential mechanism.

The Landscape Engagement target can address different pressure indicators, including land use, land use change, and soil pollution. Companies setting this target will collaborate with established local partners in priority landscapes toward improving a range of ecological and social indicators defined in alignment with these partners.