Lojuxta is a medicine that contains the active substance lomitapide. It is used to treat adult patients with homozygous familial hypercholesterolaemia, an inherited disease causing high blood levels of cholesterol (a type of fat). It is used together with a low fat diet and other medicines to reduce the level of fats in the blood.

Lomitapide, sold under the brand name Juxtapid in the US and Lojuxta in the EU, is a medication used as a lipid-lowering agent for the treatment of familial hypercholesterolemia, developed by Aegerion Pharmaceuticals. [3] It has been tested in clinical trials as single treatment and in combinations with atorvastatin, ezetimibe and fenofibrate ...

Lojuxta is indicated as an adjunct to a low-fat diet and other lipid-lowering medicinal products with or without low density lipoprotein (LDL) apheresis in adult patients with homozygous familial hypercholesterolaemia (HoFH). Genetic confirmation of HoFH should be …

纯合子家族性高胆固醇血症 (HoFH)是一种极罕见的常染色体显性遗传性疾病，发病机制为细胞膜表面的低密度脂蛋白（LDL）受体缺如或异常，导致体内LDL代谢异常，造成血浆. 美国生物制药公司Aegerion制药今天宣布，欧洲药品管理局（EMA）已批准将Lojuxta（lomitapide）硬胶囊作为低脂肪饮食及其他降脂药用产品的一种辅助药物，用于纯合子家族性高胆固醇血症（HoFH）成人患者的治疗。 纯合子家族性高胆固醇血症 (HoFH)是一种极罕见的常染色体显性遗传性疾病，发 …

Lojuxta is a medicine that contains the active substance lomitapide. It is used to treat adult patients with homozygous familial hypercholesterolaemia, an inherited disease causing high blood levels of cholesterol (a type of fat). It is used together with a low fat diet and other medicines to reduce the level of fats in the blood.

Lojuxta是一种微粒体甘油三酯转移蛋白抑制剂适用于在有纯合子家族性高胆固醇血症(HoFH)患者作为对低脂肪膳食和其他降脂治疗，包括能得到LDL血液分离，辅助减低低密度脂蛋白胆固醇(LDL-C)，总胆固醇(TC)，载脂蛋白B (载脂蛋白B)，和非高密度脂蛋白胆固醇(非-HDL-C).

2018年8月21日 · 2012年12月21日，美国食品与药物管理局（FDA）批准了洛美他派甲磺酸盐（lomitapide MESYLATE）上市，该药获准与低脂饮食和其他降脂药物一起用于治疗纯合性家族性高胆固醇血症（hoFH），降低这些患者的低密低脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、载脂蛋白B（apoB）和非高密度脂蛋白胆固醇。 该药获准与低脂饮食和其他降脂药物一起用于治疗纯合子家族性高胆固醇血症（hoFH）。 本品需每日空腹服用1次。 纯合子型家族性高胆固醇血 …

Patients taking Lojuxta should avoid consumption of grapefruit juice. When administered with atorvastatin, the dose of Lojuxta should either be taken 12 hours apart or be decreased by half (see section 4.2). The dose of Lojuxta should be taken 12 hours apart from any other concomitant weak CYP3A4 inhibitors.

Lojuxta is indicated as an adjunct to a low?fat diet and other lipid?lowering medicinal products with or without low-density-lipoprotein (LDL) apheresis in adult patients with homozygous familial hypercholesterolaemia (HoFH). Genetic confirmation of HoFH should be …

Before prescribing Lojuxta, please refer to the full Summary of Product Characteristics (SmPC)i. Active Ingredient: Each hard capsule contains 5 mg, 10 mg or 20 mg lomitapide (as lomitapide mesylate). Indication: Lojuxta is indicated as an adjunct to a low-fat diet and other lipid-lowering medicinal products with or without