Loop diuretics are a powerful type of diuretic that work by inhibiting the sodium-potassium-chloride (Na+/K+/2Cl) co-transporter in the thick ascending loop of Henle (hence the name loop diuretic), which is located in the kidneys.

The most commonly used loop diuretics are furosemide, bumetanide, and torsemide, which are sulfonamide derivatives. Ethacrynic acid is rarely used but is an alternative in patients who have a hypersensitivity reaction to a typical loop diuretic.

Loop diuretics act on the Na +-K +-2Cl − symporter (NKCC2) in the thick ascending limb of the loop of Henle to inhibit sodium, chloride and potassium reabsorption. This is achieved by competing for the Cl − binding site.

Aug 17, 2023 · Examples of loop diuretics include: Bumetanide (Bumex). Ethacrynic acid (Edecrin). Furosemide (Lasix). Torsemide (Soaanz). Examples of potassium-sparing diuretics include: Amiloride (Midamor). Eplerenone (Inspra). Spironolactone (Aldactone, Carospir). Triamterene (Dyrenium).

May 22, 2023 · Loop diuretics are medications used in the management and treatment of fluid overload conditions such as heart failure, nephrotic syndrome or cirrhosis, and hypertension, in addition to edema. This activity reviews the indications, action, and contraindications for loop diuretics as a valuable agent in managing fluid overload and hypertension.

Mar 17, 2022 · Loop diuretics are a class of medications used to cause diuresis, or increased urine flow. They differ from other types of diuretics in how they increase urine production. Other diuretic classes include thiazide diuretics, carbonic anhydrase inhibitors, and …

Loop diuretics are medications used to treat fluid overload conditions such as heart failure, nephrotic syndrome or cirrhosis, and hypertension, in addition to edema. Learn about side effects, drug names, and uses.

Apr 17, 2023 · There are several different classes of diuretics, including carbonic anhydrase inhibitors, loop diuretics, potassium-sparing diuretics, and thiazide diuretics. Each type works in a distinct way and in different parts of the kidney cell (called a nephron).