In 4 clinical trials involving over 1000 patients on various doses (10 to 150 mg) of losartan potassium and over 300 patients given placebo, the adverse events that occurred in ≥2% of patients treated with losartan potassium and more commonly than placebo were: dizziness (3% vs. 2%), upper respiratory infection (8% vs. 7%), nasal congestion ...

2024年2月29日 · Losartan side effects. Get emergency medical help if you have signs of an allergic reaction to losartan: hives, difficulty breathing, swelling of your face, lips, tongue, or throat. Losartan may cause serious side effects. Call your doctor at once if you have: a light-headed feeling, like you might pass out;

2023年8月29日 · Losartan is metabolized in the liver to an active metabolite (which has a similar action to losartan). The time to peak effect after a dose is 1-2 hours for losartan and 3-4 hours for the metabolite. At its peak level, losartan inhibits 85% of the effects of angiotensin II, and 25 to 40% of this inhibition persists for 24 hours.

2024年11月22日 · MAOIs are typically only used when other antidepressants have proven ineffective, because they have a higher risk of drug interactions than standard antidepressants and can also interact with certain types of food such as aged cheeses and cured meats.

2025年1月10日 · Neither losartan nor its active metabolite is removed by hemodialysis. Stability Storage Oral Extemporaneous Suspension. 2.5-mg/mL preparation of losartan potassium tablets in a mixture of syrup (Ora-Sweet SF) and suspending vehicle (Ora-Plus) : Up to 4 weeks at 2–8°C. Tablets. 25°C (excursions permitted between 15–30°C). Protect from ...

2024年11月26日 · The 4 studies of losartan monotherapy included a total of 1075 patients randomized to several doses of losartan and 334 to placebo. The 10- and 25-mg doses produced some effect at peak (6 hours after dosing) but small and inconsistent trough (24 hour) responses.

Hydrochlorothiazide/losartan Interactions. There are 550 drugs known to interact with hydrochlorothiazide/losartan, along with 18 disease interactions, and 3 alcohol/food interactions. Of the total drug interactions, 44 are major, 465 are moderate, and 41 are minor.

Hydrochlorothiazide 12.5 to 25 mg-Losartan 50 to 100 mg orally once a day Maximum dose: Hydrochlorothiazide 25 mg-Losartan 100 mg orally once a day Comments:-A patient whose blood pressure is not adequately controlled with hydrochlorothiazide or losartan monotherapy may be switched to hydrochlorothiazide 12.5 mg-losartan 50 mg orally once a day.

2024年11月22日 · Heparins. The heparins are a group of anticoagulants that consist of unfractionated heparin, low molecular weight heparins, and heparinoids.

2025年2月11日 · Evaluate the clinical response to losartan potassium and hydrochlorothiazide 50/12.5 and, if blood pressure remains uncontrolled after about 3 weeks of therapy, increase the dose to two tablets of losartan potassium and hydrochlorothiazide 50/12.5 once daily or one tablet of losartan potassium and hydrochlorothiazide 100/25 once daily.